Polyphenols and IUGR pregnancies : effects of the antioxidant hydroxytyrosol on the hippocampus proteome in a porcine model
Yeste, Natalia (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Pérez-Valle, Jorge (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Vázquez-Gómez, Marta (Universidad Complutense de Madrid)
García-Contreras, Consolación (Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (Espanya))
Gonzalez-Bulnes, Antonio (Universidad CEU Cardenal Herrera. Departamento de Producción y Sanidad Animal)
Bassols Teixidó, Anna Maria (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)

Date:	2022
Abstract:	Supplementation of a mother's diet with antioxidants such as hydroxytyrosol (HTX) has been proposed to ameliorate the adverse phenotypes of foetuses affected by intrauterine growth restriction (IUGR). Our previous studies showed, in a porcine model of IUGR, an effect of maternal HTX supplementation on the neurotransmitter profile of several brain areas and the morphology of the hippocampus in 100 days old foetuses. The present study analyzed the impact of maternal HTX supplementation on the hippocampus proteome at this foetal age by TMT10plex labelling. Eleven differentially abundant proteins were identified by comparing both conditions, and eight of them downregulated and three upregulated in the HTX-treated group. The downregulated proteins were mainly involved in protein synthesis and RNA metabolism and may explain the differences in neuron differentiation in the HTX-treated group. The upregulated proteins were related to cell detoxification and could represent a potential mechanism to explain the neuroprotective effect of HTX.
Grants:	Ministerio de Economía y Competitividad AGL2015-68463-C2-2-P Ministerio de Economía y Competitividad AGL2013-48121-C3-R Agencia Estatal de Investigación AGL2016-79321-C2-1-R Ministerio de Ciencia, Innovación y Universidades FPU17/01881 Ministerio de Educación, Cultura y Deporte FPU14/01285 Ministerio de Economía y Competitividad BES-2014-070464
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Hydroxytyrosol ; Hippocampus ; Intrauterine growth restriction ; Brain ; Pig ; Proteome ; TMT labelling
Published in:	Antioxidants, Vol. 11, Issue 6 (June 2022) , art. 1135, ISSN 2076-3921

DOI: 10.3390/antiox11061135
PMID: 35740029

11 p, 580.8 KB

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