Web of Science: 8 citas, Scopus: 7 citas, Google Scholar: citas,
Classical BSE prions emerge from asymptomatic pigs challenged with atypical/Nor98 scrapie
Marín, Belén (Centro de Encefalopatías y Enfermedades Transmisibles Emergentes)
Otero, Alicia (Universidad de Zaragoza. Centro de Encefalopatías y Enfermedades Transmisibles Emergentes)
Lugan, Séverine (École Nationale Vétérinaire de Toulouse)
Espinosa, Juan Carlos (Centro de Investigación en Sanidad Animal. CISA (Madrid, Espanya))
Marín-Moreno, Alba (Centro de Investigación en Sanidad Animal. CISA (Madrid, Espanya))
Vidal Barba, Enric (Institut de Recerca i Tecnologia Agroalimentàries. Centre de Recerca en Sanitat Animal)
Hedman, Carlos (Centro de Encefalopatías y Enfermedades Transmisibles Emergentes)
Romero, Antonio (Universidad de Zaragoza. Servicio de Cirugía y Medicina Equina)
Pumarola i Batlle, Martí (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals)
Badiola, Juan José (Universidad de Zaragoza. Centro de Encefalopatías y Enfermedades Transmisibles Emergentes)
Torres, Juan María (Centro de Investigación en Sanidad Animal. CISA (Madrid, Espanya))
Andreoletti, Olivier (École Nationale Vétérinaire de Toulouse)
Bolea, Rosa (Universidad de Zaragoza. Centro de Encefalopatías y Enfermedades Transmisibles Emergentes)

Fecha: 2021
Resumen: Pigs are susceptible to infection with the classical bovine spongiform encephalopathy (C-BSE) agent following experimental inoculation, and PrPSc accumulation was detected in porcine tissues after the inoculation of certain scrapie and chronic wasting disease isolates. However, a robust transmission barrier has been described in this species and, although they were exposed to C-BSE agent in many European countries, no cases of natural transmissible spongiform encephalopathies (TSE) infections have been reported in pigs. Transmission of atypical scrapie to bovinized mice resulted in the emergence of C-BSE prions. Here, we conducted a study to determine if pigs are susceptible to atypical scrapie. To this end, 12, 8-9-month-old minipigs were intracerebrally inoculated with two atypical scrapie sources. Animals were euthanized between 22- and 72-months post inoculation without clinical signs of TSE. All pigs tested negative for PrPSc accumulation by enzyme immunoassay, immunohistochemistry, western blotting and bioassay in porcine PrP mice. Surprisingly, in vitro protein misfolding cyclic amplification demonstrated the presence of C-BSE prions in different brain areas from seven pigs inoculated with both atypical scrapie isolates. Our results suggest that pigs exposed to atypical scrapie prions could become a reservoir for C-BSE and corroborate that C-BSE prions emerge during interspecies passage of atypical scrapie.
Derechos: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. Creative Commons
Lengua: Anglès
Documento: Article ; recerca ; Versió publicada
Materia: Malalties priòniques en els animals
Publicado en: Scientific reports, Vol. 11 Núm. 1 (2021) , ISSN 2045-2322

DOI: 10.1038/s41598-021-96818-2
PMID: 34465826


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