Novel sensing algorithm for linear read-out of bimodal waveguide interferometric biosensors
Bassols-Cornudella, Bernat (Institut Català de Nanociència i Nanotecnologia)
Ramirez Priego, Patricia (Institut Català de Nanociència i Nanotecnologia)
Soler Aznar, Maria (Institut Català de Nanociència i Nanotecnologia)
Estévez, M. Carmen (Institut Català de Nanociència i Nanotecnologia)
Díaz-Luisravelo, Heriberto J (Institut Català de Nanociència i Nanotecnologia)
Cardenosa-Rubio, Maria (Institut Català de Nanociència i Nanotecnologia)
Lechuga, Laura M (Institut Català de Nanociència i Nanotecnologia)

Date:	2022
Abstract:	Biosensors employing photonics integrated circuits, and specifically those that rely on interferometric evanescent wave working principles, have outstanding performances due to the extreme sensitivity exhibited in one-step and direct assay, without the need of amplification. Within the interferometric configurations, the Bimodal Waveguide (BiMW) interferometric sensor stands out due to its demonstrated sensitivity for real-life applications and the simplicity of its design. To overcome the ambiguities that arise from the periodic nature of interferometric read-outs, a new all-optical modulation and the subsequent trigonometry-based algorithm have been proposed and applied to the BiMW biosensor. This new algorithm has been successfully employed for the selective identification and quantification of the external Spike (S) protein of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Our biosensing results from this simple, quick, and user-friendly method demonstrate high sensitivity and specificity and pave the way towards a point-of-care device for general use.
Grants:	European Commission 101003544 Agencia Estatal de Investigación SEV-2017-0706
Note:	Altres ajuts: the ICN2 was supported by the CERCA programme of the Generalitat de Catalunya.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Biosensors ; Integrated optics ; Silicon photonics ; Waveguide interferometry ; Coronavirus
Published in:	Journal of Lightwave Technology, Vol. 40, issue 1 (Jan. 2022) , p. 237-244, ISSN 1558-2213

DOI: 10.1109/JLT.2021.3118103

8 p, 994.1 KB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Experimental sciences > Catalan Institute of Nanoscience and Nanotechnology (ICN2)
Articles > Research articles
Articles > Published articles