The role of neurotrophin genes involved in the vulnerability to gambling disorder
Solé-Morata, Neus (Hospital Universitari de Bellvitge)
Baenas Soto, Isabel Maria (Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición)
Etxandi Santolaya, Mikel (Hospital Universitari de Bellvitge)
Granero, Roser (Universitat Autònoma de Barcelona. Departament de Psicobiologia i de Metodologia de les Ciències de la Salut)
Forcales, Sònia Vanina (Universitat de Barcelona. Departament de Patologia i Terapèutica Experimental)
Gené Badia, Manel (Universitat de Barcelona. Laboratori de Genètica Forense)
Barrot, Carme (Universitat de Barcelona. Laboratori de Genètica Forense)
Gomez-Peña, Monica (Institut d'Investigació Biomèdica de Bellvitge)
Menchón Magriñá, José Manuel (Institut d'Investigació Biomèdica de Bellvitge)
Ramoz, Nicolas (Université de Paris. Institute of Psychiatry and Neuroscience of Paris (IPNP))
Gorwood, Philip (Université de Paris. Institute of Psychiatry and Neuroscience of Paris (IPNP))
Fernández Aranda, Fernando (Universitat de Barcelona. Departament de Ciències Clíniques)
Jiménez Murcia, Susana (Universitat de Barcelona. Departament de Ciències Clíniques)

Date:	2022
Abstract:	Evidence about the involvement of genetic factors in the development of gambling disorder (GD) has been assessed. Among studies assessing heritability and biological vulnerability for GD, neurotrophin (NTF) genes have emerged as promising targets, since a growing literature showed a possible link between NTF and addiction-related disorders. Thus, we aimed to explore the role of NTF genes and GD with the hypothesis that some NTF gene polymorphisms could constitute biological risk factors. The sample included 166 patients with GD and 191 healthy controls. 36 single nucleotide polymorphisms (SNPs) from NTFs (NGF, NGFR, NTRK1, BDNF, NTRK2, NTF3, NTRK3, NTF4, CNTF and CNTFR) were selected and genotyped. Linkage disequilibrium (LD) and haplotype constructions were analyzed, in relationship with the presence of GD. Finally, regulatory elements overlapping the identified SNPs variants associated with GD were searched. The between groups comparisons of allele frequencies indicated that 6 SNPs were potentially associated with GD. Single and multiple-marker analyses showed a strong association between both NTF3 and NTRK2 genes, and GD. The present study supports the involvement of the NTF family in the aetiopathogenesis of GD. An altered cross-regulation of different NTF members signalling pathways might be considered as a biological vulnerability factor for GD.
Grants:	Ministerio de Ciencia, Innovación y Universidades RTI2018-101837-B-100 Instituto de Salud Carlos III PI17/01167 Instituto de Salud Carlos III PI20/00132
Note:	Altres ajuts: Delegación del Gobierno para el Plan Nacional sobre Drogas (2021I031 and 2019I47), EU Grant Eat2beNice (H2020-SFS-2016-2; Ref728018), PRIME (H2020-SC1-BHC-2018-2020, ref.847879) and COST Action (CA19115).
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Predictive markers ; Addiction
Published in:	Scientific reports, Vol. 12 (april 2022) , ISSN 2045-2322

DOI: 10.1038/s41598-022-10391-w
PMID: 35484167

11 p, 1.4 MB

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