Interaction of nanoparticles with endotoxin Importance in nanosafety testing and exploitation for endotoxin binding
Mangini, MARIA (Istituto di Biochimica e Biologia Cellulare (Nàpols, Itàlia))
Verde, Alessandro (Istituto di Biochimica e Biologia Cellulare (Nàpols, Itàlia))
Boraschi, Diana (Istituto di Biochimica e Biologia Cellulare (Nàpols, Itàlia))
Puntes, Víctor (Institut Català de Nanociència i Nanotecnologia)
Italiani, Paola (Istituto di Biochimica e Biologia Cellulare (Nàpols, Itàlia))
De Luca, Anna Chiara (Istituto di Biochimica e Biologia Cellulare (Nàpols, Itàlia))

Date:	2021
Abstract:	The interaction between engineered nanoparticles and the bacterial lipopolysaccharide, or endotoxin, is an event that warrants attention. Endotoxin is one of the most potent stimulators of inflammation and immune reactions in human beings, and is a very common contaminant in research labs. In nanotoxicology and nanomedicine, the presence of endotoxin on the nanoparticle surface affects their biological properties leading to misinterpretation of results. This review discusses the importance of detecting the endotoxin contamination on nanoparticles, focusing on the current method of endotoxin detection and their suitability for nanoparticulate materials. Conversely, the capacity of nanoparticles to bind endotoxin can be enhanced by functionalization with endotoxin-capturing molecules, opening the way to the development of novel endotoxin detection assays.
Grants:	European Commission 812661 European Commission 671881
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Nanoparticles ; Endotoxin ; Inflammation ; LPSsensors ; SERS
Published in:	Nanotoxicology, Vol. 15, issue 4 (2021) , p. 558-576, ISSN 1743-5404

DOI: 10.1080/17435390.2021.1898690

20 p, 3.3 MB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Experimental sciences > Catalan Institute of Nanoscience and Nanotechnology (ICN2)
Articles > Research articles
Articles > Published articles