Brain networks alterations in cocaine use and gambling disorders during emotion regulation
Picó-Pérez, Maria (Universitat Jaume I. Departament de Psicologia Bàsica, Clínica i Psicobiologia)
Costumero, Víctor (Universitat Jaume I. Departament de Psicologia Bàsica, Clínica i Psicobiologia)
Verdejo-Román, Juan (University of Granada. Department of Personality, Assessment and Clinical Treatment)
Albein-Urios, Natalia (Deakin University. Cognitive Neuroscience Unit, School of Psychology)
Martínez-González, José Miguel (Diputación de Granada. Centro Provincial de Drogodependencias)
Soriano-Mas, Carles (Universitat Autònoma de Barcelona. Departament de Psicobiologia i de Metodologia de Ciències de la Salut)
Barrós-Loscertales, Alfonso (Universitat Jaume I. Departament de Psicologia Bàsica, Clínica i Psicobiologia)
Verdejo-Garcia, Antonio (Monash University. Monash Institute of Cognitive and Clinical Neurosciences)

Date:	2022
Abstract:	Cocaine use disorder (CUD) and gambling disorder (GD) share clinical features and neural alterations, including emotion regulation deficits and dysfunctional activation in related networks. However, they also exhibit differential aspects, such as the neuroadaptive effects of long-term drug consumption in CUD as compared to GD. Neuroimaging research aimed at disentangling their shared and specific alterations can contribute to improve understanding of both disorders. We compared CUD (N = 15), GD (N = 16) and healthy comparison (HC; N = 17) groups using a network-based approach for studying temporally coherent functional networks during functional magnetic resonance imaging (fMRI) of an emotion regulation task. We focused our analysis in limbic, ventral frontostriatal, dorsal attentional (DAN) and executive networks (FPN), given their involvement in emotion regulation and their alteration in CUD and GD. Correlations with measures of emotional experience and impulsivity (UPPS-P) were also performed. The limbic network was significantly decreased during emotional processing both for CUD and GD individuals compared to the HC group. Furthermore, GD participants compared to HC showed an increased activation in the ventral frontostriatal network during emotion regulation. Finally, networks' activation patterns were modulated by impulsivity traits. Functional network analyses revealed both overlapping and unique effects of stimulant and gambling addictions on neural networks underpinning emotion regulation.
Grants:	Ministerio de Ciencia e Innovación IJC2019-041916-I
Note:	Altres ajuts: The study was funded by the grant COPERNICO from the Spanish Ministry of Health/National Drugs Plan, and by the Norte Portugal Regional Operational Programme (NORTE 2020) under the Portugal 2020 Partnership Agreement (NORTE-01-0145-FEDER-000013 and NORTE-01-0145-FEDER-000023). VC was supported by the grant PID2019-105077RJ-I00/AEI/10.13039/501100011033. AVG was supported by a Medical Research Future Fund fellowship (MRF1141214). ABL has received research support from the Universitat Jaume I (UJI-B2020-23). MPP was supported by the Spanish Ministry of Universities, with funds from the European Union - NextGenerationEU (MAZ/2021/11).
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Addiction ; Cocaine ; Emotion regulation ; Fmri ; Gambling ; Independent-component analysis
Published in:	Journal of behavioral addictions, Vol. 11 (april 2022) , p. 373-385, ISSN 2063-5303

DOI: 10.1556/2006.2022.00018
PMID: 35460545

13 p, 1.6 MB

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