Novel cannabinoid release system : encapsulation of a cannabidiol precursor into γ-cyclodextrin metal-organic frameworks
Rodriguez Martinez, Jorge (Universitat Autònoma de Barcelona. Departament de Química)
Sánchez-Martín, María-Jesús (Universitat Autònoma de Barcelona. Departament de Química)
López Patarroyo, Oscar (Universitat Autònoma de Barcelona. Departament de Química)
Valiente Malmagro, Manuel (Universitat Autònoma de Barcelona. Departament de Química)

Fecha:	2022
Descripción:	8 pàg.
Resumen:	γ-Cyclodextrin-metal-organic frameworks (γ-CD-MOFs) are developed as a new promising and biocompatible material, which shows a great potential for drug delivery system (DDS) applications. γ-CD-MOFs were successfully synthesized using microwave-assisted technique from different potassium sources (KOH, KCl and KNO3). The encapsulation of olivetol (OLV) into these materials was investigated as an innovative model of DDS for cannabinoids. Loading of OLV in γ-CD-MOFs was performed by impregnation and co-crystallization methods. Scanning electron microscopy (SEM) and X-ray powder diffraction (XRPD) were employed to study the structural properties of γ-CD-MOF samples, showing the typical cubic crystals in case of KOH and trigonal morphologies in case of KCl and KNO3. Olivetol content was determined using UV-Vis spectrophotometry and its interaction with γ-CD-MOFs was investigated by Attenuated Total Reflection-Fourier Transform Infrared Spectroscopy analysis (ATR-FTIR). OLV content was significantly higher when KCl or KNO3 were employed in combination with a cocrystallization method, while the drug encapsulation using KOH and the impregnation method was really poor. For the first time, γ-CD-MOFs loaded with cannabinoids were developed and they could be considered a novel strategy as DDS of these compounds.
Ayudas:	Ministerio de Economía y Competitividad CTM2015-65414-C2-1-R
Nota:	Altres ajuts: acords transformatius de la UAB
Nota:	Altres ajuts: Jorge Rodríguez-Martínez acknowledges Agència de Gestió d'Ajuts Universitaris i de Recerca from Generalitat de Catalunya (Sapin) for the FI-2018 fellowship.
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	γ-Cyclodextrin-metal-organic frameworks ; (γ-CD-MOFs) ; Cannabidiol (CBD) ; Cannabinoids ; Drug delivery systems (DDS) ; Olivetol (OLV)
Publicado en:	Journal of Drug Delivery Science and Technology, Vol. 79 (2022) , art. 104085, ISSN 2588-8943

DOI: 10.1016/j.jddst.2022.104085

8 p, 3.0 MB

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