Repurposing Itraconazole and Hydroxychloroquine to Target Lysosomal Homeostasis in Epithelial Ovarian Cancer
Marastoni, Stefano (University Health Network (Canadà))
Madariaga, Ainhoa (Universitat Autònoma de Barcelona)
Pesic, Aleksandra (University Health Network (Canada))
Nair, Sree Narayanan (University Health Network (Canada))
Li, Zhu Juan (University Health Network (Canada))
Shalev, Zvi (University Health Network (Canada))
Ketela, Troy (University Health Network (Canada))
Colombo, Ilaria (University Health Network (Canada))
Mandilaras, Victoria (University Health Network (Canada))
Cabanero, Michael (University Health Network (Canada))
Bruce, Jeff P. (University Health Network (Canada))
Li, Xuan (University Health Network (Canada))
Garg, Swati (University Health Network (Canada))
Wang, Lisa (University Health Network (Canada))
Chen, Eric X. (University Health Network (Canada))
Gill, Sarbjot (University Health Network (Canada))
Dhani, Neesha C. (University Health Network (Canada))
Zhang, Wenjiang (University Health Network (Canada))
Pintilie, Melania (University Health Network (Canada))
Bowering, Valerie (University Health Network (Canada))
Koritzinsky, Marianne (University Health Network (Canada))
Rottapel, Robert (University Health Network (Canada))
Wouters, Bradly G. (Department of Radiation Oncology, University of Toronto)
Oza, Amit M. (University Health Network (Canada))
Joshua, Anthony M. (Garvan Institute of Medical Research (Austràlia))
Lheureux, Stephanie (Princess Margaret Cancer Centre)

Date:	2022
Abstract:	The combination of the antifungal drug itraconazole with antimalarial drug hydroxychloroquine leads to a cytotoxic lysosomal dysfunction, supporting the rational for further research on lysosomal targeting in ovarian cancer.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Published in:	Cancer Research Communications, Vol. 2 (may 2022) , p. 293-306, ISSN 2767-9764

DOI: 10.1158/2767-9764.CRC-22-0037
PMID: 36875717

14 p, 14.9 MB

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