Genetic diversity in casein gene cluster in a dromedary camel (C. dromedarius) population from the United Arab Emirates
Mutery, Abdullah (University of Sharjah. Department of Applied Biology)
Rais, Naushad (Manipal Academy of Higher Education. School of Life Sciences)
Mohamed, Kamal Eldin Walaa (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
Tlili, Abdelaziz (University of Sharjah. Research Institute of Sciences & Engineering)

Date:	2021
Abstract:	Genetic polymorphisms, causing variation in casein genes (CSN1S1, CSN1S2, CSN2, and CSN3), have been extensively studied in goats and cows, but there are only few studies reported in camels. Therefore, we aimed to identify alleles with functional roles in the United Arab Emirates dromedary camel (Camelus dromedarius) population to complement previous studies conducted on the same species. Using targeted next-generation sequencing, we sequenced all genes in the casein gene cluster in 93 female camels to identify and characterize novel gene variants. Most variants were found in noncoding introns and upstream sequences, but a few variants showed the possibility of functional impact. CSN2 was found to be most polymorphic, with total 91 different variants, followed by CSN1S1, CSN3 and CSN1S2. CSN1S1, CSN1S2 and CSN2 each had at least two variants while CSN3 had only one functional allele. In future research, the functional impact of these variants should be investigated further.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Casein ; CSN1S1 ; CSN1S2 ; CSN2 and CSN3 ; Camel ; Dromedary ; Next generation DNA sequencing ; Casein genetic variability ; The UAE
Published in:	Genes, Vol. 12, issue 9 (Sep. 2021) , ISSN 2073-4425

DOI: 10.3390/genes12091417
PMID: 34573399

8 p, 253.4 KB

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