Heterogeneous rate constant for amorphous silica nanoparticle adsorption on phospholipid monolayers
Vakurov, Alex (University of Leeds. School of Chemistry)
Drummond-Brydson, Rik (University of Leeds. School of Chemical and Process Engineering)
William, Nicola (University of Leeds. School of Chemistry)
Sanver, Didem (Necmettin Erbakan University. Department of Food Engineering)
Bastús, Neus G. (Institut Català de Nanociència i Nanotecnologia)
Moriones, Oscar Hernando (Institut Català de Nanociència i Nanotecnologia)
Puntes, Víctor (Institut Català de Nanociència i Nanotecnologia)
Nelson, Andrew L. (University of Leeds. School of Chemistry)

Date:	2022
Abstract:	The interaction of amorphous silica nanoparticles with phospholipid monolayers and bilayers has received a great deal of interest in recent years and is of importance for assessing potential cellular toxicity of such species, whether natural or synthesized for the purpose of nanomedical drug delivery and other applications. This present communication studies the rate of silica nanoparticle adsorption on to phospholipid monolayers in order to extract a heterogeneous rate constant from the data. This rate constant relates to the initial rate of growth of an adsorbed layer of nanoparticles as SiO on a unit area of the monolayer surface from unit concentration in dispersion. Experiments were carried out using the system of dioleoyl phosphatidylcholine (DOPC) monolayers deposited on Pt/Hg electrodes in a flow cell. Additional studies were carried out on the interaction of soluble silica with these layers. Results show that the rate constant is effectively constant with respect to silica nanoparticle size. This is interpreted as indicating that the interaction of hydrated SiO molecular species with phospholipid polar groups is the molecular initiating event (MIE) defined as the initial interaction of the silica particle surface with the phospholipid layer surface promoting the adsorption of silica nanoparticles on DOPC. The conclusion is consistent with the observed significant interaction of soluble SiO with the DOPC layer and the established properties of the silica-water interface.
Grants:	European Commission 862296 European Commission 685817 European Commission 229244
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Adsorption ; Colloids ; Layers ; Nanoparticles ; Silica
Published in:	Langmuir, Vol. 38, issue 18 (May 2022) , p. 5372-5380, ISSN 1520-5827

DOI: 10.1021/acs.langmuir.1c03155
PMID: 35471829

9 p, 1.4 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Experimental sciences > Catalan Institute of Nanoscience and Nanotechnology (ICN2)
Articles > Research articles
Articles > Published articles