Diverse infectivity, transmissibility, and pathobiology of clade 2.3.4.4 H5Nx highly pathogenic avian influenza viruses in chickens
Kwon, Jung-Hoon (Kyungpook National University)
Bertran, Kateri (Universitat Autònoma de Barcelona. Unitat Mixta d'Investigació IRTA-UAB en Sanitat Animal)
Lee, Dong-Hun (Konkuk University)
Criado, Miria Ferreira (Auburn University)
Killmaster, Lindsay (U.S. National Poultry Research Center)
Pantin-Jackwood, Mary J. (U.S. National Poultry Research Center)
Swayne, David E. (U.S. National Poultry Research Center)

Fecha:	2023
Resumen:	Clade 2. 3. 4. 4 Eurasian lineage H5Nx highly pathogenic avian influenza virus (HPAIV) has become the globally dominant clade and caused global outbreaks since 2014. The clade 2. 3. 4. 4 viruses have evolved into eight hemagglutinin subgroups (2. 3. 4. 4a-h). In this study, we evaluated the infectivity, pathobiology, and transmissibility of seven clade 2. 3. 4. 4 viruses (two 2. 3. 4. 4a, two 2. 3. 4. 4b, one 2. 3. 4. 4c and two 2. 3. 4. 4e) in chickens. The two clade 2. 3. 4. 4e viruses caused 100% mortality and transmissibility in chickens. However, clade 2. 3. 4. 4a and c viruses showed 80-90% mortality and 67% transmissibility. Clade 2. 3. 4. 4b viruses showed 100% mortality, but no transmission to co-housed chickens was observed based on lack of seroconversion. All the infected chickens died showing systemic infection, irrespective of subgroup. The results highlight that all the clade 2. 3. 4. 4 HPAIVs used in this study caused high mortality in infected chickens, but the transmissibility of the viruses in chickens was variable in contrast to that of previous Eurasian-lineage H5N1 HPAIVs. Changes in the pathogenicity and transmissibility of clade 2. 3. 4. 4 HPAIVs warrant careful monitoring of the viruses to establish effective control strategies.
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons en que s'entrega l'obra al domini públic. Podeu copiar, modificar, distribuir l'obra i fer-ne comunicació pública, fins i tot amb finalitat comercial, sense demanar cap mena de permís.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Avian influenza virus ; Highly pathogenic avian influenza virus ; Clade 2.3.4.4 ; Infectivity ; Pathogenicity ; Transmissibility ; Chicken
Publicado en:	Emerging microbes & infections, Vol. 12 (june 2023) , ISSN 2222-1751

DOI: 10.1080/22221751.2023.2218945
PMID: 37309051

10 p, 1.9 MB

El registro aparece en las colecciones:
Documentos de investigación > Documentos de los grupos de investigación de la UAB > Centros y grupos de investigación (producción científica) > Ciencias de la salud y biociencias > Centre de Recerca en Sanitat Animal (CReSA-IRTA)
Artículos > Artículos de investigación
Artículos > Artículos publicados