Benchmarking of survival outcomes following Haematopoietic Stem Cell Transplantation (HSCT) : an update of the ongoing project of the European Society for Blood and Marrow Transplantation (EBMT) and Joint Accreditation Committee of ISCT and EBMT (JACIE)
Saccardi, Riccardo (Careggi University Hospital (Florència, Itàlia))
Putter, Hein (Leiden University Medical Center)
Eikema, Dirk-Jan (EBMT Statistical Unit Leiden)
Busto, María Paula (EBMT Registry)
McGrath, Eoin (ICCBBA (Barcelona, Espanya))
Middelkoop, Bas (European Society for Blood and Marrow Transplantation-EBMT Registry)
Adams, Gillian (European Society for Blood and Marrow Transplantation-EBMT Executive Office (Barcelona, Espanya))
Atlija, Marina (European Society for Blood and Marrow Transplantation-EBMT Registry)
Ayuk, Francis (University Medical Center Hamburg)
Baldomero, Helen (University Hospital Basel (Basilea, Suïssa))
Beguin, Yves (CHU of Liège and University of Liège)
de la Camara, Rafael (European Society for Blood and Marrow Transplantation-EBMT Executive Office (Barcelona, Espanya))
Cedillo Cedillo, Angel (Grupo Español de Trasplantes Hematopoyéticos y Terapia Celular)
Balari, Anna María Sureda (Hospital Universitari de Bellvitge)
Chabannon, Christian (Institut Paoli-Calmettes Comprehensive Cancer Centre)
Corbacioglu, Selim (University Children's Hospital Regensburg)
Dolstra, Harry (Radboud University Medical Center)
Duarte, Rafael (Universidad Autónoma de Madrid)
Duléry, Rémy (Sorbonne Université)
Greco, Raffaella (Autoimmune Diseases Working Party (Barcelona, Espanya))
Gusi, Andreu (European Society for Blood and Marrow Transplantation-EBMT Executive Office (Barcelona, Espanya))
Hamad, Nada (University of Notre Dame Australia)
Kenyon, Michelle (King's College Hospital NHS Foundation Trust)
Kroeger, Nicolaus (University Medical Center Hamburg)
Labopin, Myriam (European Society for Blood and Marrow Transplantation-EBMT Paris Study Office)
Lee, Julia (British Society of Blood and Marrow Transplantation and Cellular Therapy (Regne Unit))
Ljungman, Per (Karolinska University Hospital and Karolinska Institutet (Suècia))
Manson, Lynn (Edinburgh & SE Scotland Clinical Transfusion Centre Patient Services (Regne Unit))
Mensil, Florence (Agence de la Biomédecine)
Milpied, Noel (Centre Hospitalier Universitaire Bordeaux)
Mohty, Mohamad (Sorbonne University)
Oldani, Elena (Italian National BMT Registry)
Orchard, Kim (University Hospital Southampton NHS)
Passweg, Jakob (University Hospital Basel (Basilea, Suïssa))
Pearce, Rachel (British Society of Blood and Marrow Transplantation and Cellular Therapy (Regne Unit))
de Latour, Régis Peffault (BMT unit Paris Cité University)
Poirel, Hélène A. (Belgian Transplant Registry)
Rintala, Tuula (King's College Hospital NHS Foundation Trust)
Rizzo, J. Douglas (CIBMTR, Medical College of Wisconsin)
Ruggeri, Annalisa (IRCCS San Raffaele Scientific Institute (Milà, Itàlia))
Sanchez-Martinez, Carla (European Society for Blood and Marrow Transplantation-EBMT Executive Office (Barcelona, Espanya))
Sanchez-Guijo, Fermin (CIC-University of Salamanca)
Sánchez-Ortega, Isabel (European Society for Blood and Marrow Transplantation-EBMT Executive Office (Barcelona, Espanya))
Trnková, Marie (Czech registry Czech Republic)
Valcárcel, David (Vall d'Hebron Institut d'Oncologia)
Wilcox, Leonie (Australasian Bone Marrow Transplant Recipient Registry)
de Wreede, Liesbeth C. (Leiden University Medical Center)
Snowden, John A. (Sheffield Teaching Hospitals NHS Foundation Trust (Sheffield, Regne Unit))
Universitat Autònoma de Barcelona

Fecha:	2023
Resumen:	From 2016 EBMT and JACIE developed an international risk-adapted benchmarking program of haematopoietic stem cell transplant (HSCT) outcome to provide individual EBMT Centers with a means of quality-assuring the HSCT process and meeting FACT-JACIE accreditation requirements relating to 1-year survival outcomes. Informed by previous experience from Europe, North America and Australasia, the Clinical Outcomes Group (COG) established criteria for patient and Center selection, and a set of key clinical variables within a dedicated statistical model adapted to the capabilities of the EBMT Registry. The first phase of the project was launched in 2019 to test the acceptability of the benchmarking model through assessment of Centers' performance for 1-year data completeness and survival outcomes of autologous and allogeneic HSCT covering 2013-2016. A second phase was delivered in July 2021 covering 2015-2019 and including survival outcomes. Reports of individual Center performance were shared directly with local principal investigators and their responses were assimilated. The experience thus far has supported the feasibility, acceptability and reliability of the system as well as identifying its limitations. We provide a summary of experience and learning so far in this 'work in progress', as well as highlighting future challenges of delivering a modern, robust, data-complete, risk-adapted benchmarking program across new EBMT Registry systems.
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Haematological cancer ; Therapeutics
Publicado en:	Bone marrow transplantation, march 2023, p. 1-8, ISSN 1476-5365

DOI: 10.1038/s41409-023-01924-6
PMID: 36894635

8 p, 1.8 MB

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