Increasing trend of antimicrobial resistance in Shigella associated with MSM transmission in Barcelona, 2020-21 : outbreak of XRD Shigella sonnei and dissemination of ESBL-producing Shigella flexneri
Moreno-Mingorance, Albert (Hospital Universitari Vall d'Hebron)
Mir-Cros, Alba (Hospital Universitari Vall d'Hebron)
Goterris, Lidia (Hospital Universitari Vall d'Hebron)
Rodríguez Garrido, Virginia (Hospital Universitari Vall d'Hebron)
Sulleiro Igual, Elena (Hospital Universitari Vall d'Hebron)
Barberà, Maria Jesús (Hospital Universitari Vall d'Hebron)
Alberny, Mireia (Institut Català de la Salut)
Hoyos Mallecot, Yannick (Hospital Universitari Vall d'Hebron)
Descalzo, Vicente (Institut Català de la Salut)
Bravo, Albert (Hospital Universitari Vall d'Hebron)
Roca Grande, Josep (Hospital Universitari Vall d'Hebron)
Viñado, Belén (Hospital Universitari Vall d'Hebron)
Pumarola Suñé, Tomàs (Hospital Universitari Vall d'Hebron)
Larrosa, María Nieves (Hospital Universitari Vall d'Hebron)
González-López, Juanjo 1975- (Hospital Universitari Vall d'Hebron)
Universitat Autònoma de Barcelona

Date:	2023
Abstract:	Several countries have recently reported the detection of ESBL-producing Shigella sonnei associated with transmission among MSM. In a previous study by our group, 2. 8% of Shigella spp. obtained from MSM in Barcelona between 2015 and 2019 were ESBL producers. To describe and characterize the emerging ESBL-producing Shigella spp. associated with sexual transmission among MSM detected from 2020 to 2021 in Barcelona, elucidating their connectivity with contemporaneous ESBL-producing Shigella spp. from other countries. From 2020 to 2021, we identified that among MSM, 68% of S. sonnei were XDR harbouring bla and 14% of Shigella flexneri were MDR harbouring bla . WGS analysis showed that the ESBL-producing S. sonnei were part of a monophyletic cluster, which included isolates responsible for the prolonged outbreak occurring in the UK. Our data also reveal the first emergence and clonal dissemination of ESBL-producing and fluoroquinolone-resistant S. flexneri 2a among MSM. We report an increasing trend of antimicrobial resistance in Shigella spp. among MSM in Barcelona since 2021, mainly as a consequence of the dissemination of XDR ESBL-producing S. sonnei, previously reported in the UK. These results highlight the importance of international collaborative surveillance of MDR/XDR S. sonnei and S. flexneri for rapid identification of their emergence and the prevention of the transmission of these pathogens.
Grants:	Ministerio de Economía y Competitividad RD16/0016/0003
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Published in:	Journal of antimicrobial chemotherapy, Vol. 78 (february 2023) , p. 975-982, ISSN 1460-2091

DOI: 10.1093/jac/dkad031
PMID: 36760088

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