Identification of HIV-reservoir cells with reduced susceptibility to antibody-dependent immune response
Astorga-Gamaza, Antonio (Hospital Universitari Vall d'Hebron)
Grau Expósito, Judith (Hospital Universitari Vall d'Hebron)
Burgos, Joaquín (Hospital Universitari Vall d'Hebron)
Navarro, Jordi (Hospital Universitari Vall d'Hebron)
Curran, Adrian (Hospital Universitari Vall d'Hebron)
Planas, Bibiana (Hospital Universitari Vall d'Hebron)
Suanzes, Paula (Hospital Universitari Vall d'Hebron)
Falcó, Vicenç (Hospital Universitari Vall d'Hebron)
Genescà Ferrer, Meritxell (Hospital Universitari Vall d'Hebron)
Buzón, Maria José (Hospital Universitari Vall d'Hebron)
Universitat Autònoma de Barcelona

Date:	2022
Abstract:	Human immunodeficiency virus (HIV) establishes a persistent infection in heterogeneous cell reservoirs, which can be maintained by different mechanisms including cellular proliferation, and represent the main obstacle to curing the infection. The expression of the Fcγ receptor CD32 has been identified as a marker of the active cell reservoirs in people on antiretroviral therapy (ART), but if its expression has any role in conferring advantage for viral persistence is unknown. Here, we report that HIV-infected cells expressing CD32 have reduced susceptibility to natural killer (NK) antibody-dependent cell cytotoxicity (ADCC) by a mechanism compatible with the suboptimal binding of HIV-specific antibodies. Infected CD32 cells have increased proliferative capacity in the presence of immune complexes, and are more resistant to strategies directed to potentiate NK function. Remarkably, reactivation of the latent reservoir from antiretroviral-treated people living with HIV increases the pool of infected CD32 cells, which are largely resistant to the ADCC immune mechanism. Thus, we report the existence of reservoir cells that evade part of the NK immune response through the expression of CD32.
Grants:	Ministerio de Economía y Competitividad SAF2015-67334-R Agencia Estatal de Investigación RTI2018-101082-B
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	HIV ; Immune resistance ; Reservoir ; Viruses
Published in:	eLife, Vol. 11 (may 2022) , ISSN 2050-084X

DOI: 10.7554/eLife.78294
PMID: 35616530

25 p, 1.8 MB

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