Canine Mammary Neoplasia Induces Variations in the Peripheral Blood Levels of CD20, CD45RA, and CD99
Galadima, Makchit (Sciomics GmbH)
Kotova, Iuliia (Sciomics GmbH)
Schmidt, Ronny (Sciomics GmbH)
Pastor Milán, Josep (Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments)
Schröder, Christoph (Sciomics GmbH)
Rodríguez Gil, Joan Enric (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals)
Rivera del Álamo, Maria Montserrat (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals)

Fecha:	2023
Descripción:	14 pàg.
Resumen:	The idea of using tumour biomarkers as diagnostic tools is progressively increasing. Of these, serum biomarkers are of particular interest, as they can provide rapid results. In the present study, serum samples from 26 bitches diagnosed with mammary tumours, plus 4 healthy bitches, were obtained. The samples were analysed using CD antibody microarrays targeting 90 CD surface markers and 56 cytokines/chemokines. A total of five CD proteins, namely CD20, CD45RA, CD53, CD59, and CD99, were selected and further analysed, utilizing immunoblotting techniques to validate the microarray results. CD45RA showed a significantly lower abundance in the serum samples from the bitches carrying mammary neoplasia in comparison to the healthy animals. Regarding CD99, the serum samples from the neoplastic bitches showed it in a significantly higher abundance than those from the healthy patients. Finally, CD20 showed a significantly higher abundance in bitches carrying a malignant mammary tumour in comparison to healthy patients, but no differential expression between malignant and benign tumours was observed. According to these results, both CD99 and CD45RA are indicators of mammary tumour presence, but without distinguishing between malignant and benign.
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	CD20 ; CD45RA ; CD99 ; Canine mammary tumours ; Serum biomarkers
Publicado en:	International journal of molecular sciences, Vol. 24 Núm. 11 (2023) , p. 9222-14, ISSN 1422-0067

Adreça original del document, elimineu-la del registre: https://egreta.uab.cat/ws/files/369882511/ijms_24_09222.pdf
DOI: 10.3390/ijms24119222
PMID: 37298173

14 p, 1.3 MB

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