Pattern of long-term weight and metabolic changes after a first episode of psychosis : Results from a 10-year prospective follow-up of the PAFIP program for early intervention in psychosis cohort
Vázquez-Bourgon, J. (Universidad de Cantabria)
Gómez-Revuelta, M. (Universidad de Cantabria)
Mayoral-van Son, J. (Universidad Hospital Virgen del Rocio-IBiS)
Labad, Javier (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Ortiz García de la Foz, Víctor (Hospital Universitario Marqués de Valdecilla-Instituto de Investigación Marqués de Valdecilla (IDIVAL))
Setién-Suero, E. (Hospital Universitario Marqués de Valdecilla-Instituto de Investigación Marqués de Valdecilla (IDIVAL))
Ayesa-Arriola, Rosa (Centro de Investigación Biomédica en Red de Salud Mental)
Tordesillas-Gutiérrez, D. (Centro de Investigación Biomédica en Red de Salud Mental)
Juncal-Ruiz, M. (Sierrallana Hospital-Instituto de Investigación Marqués de Valdecilla (IDIVAL))
Crespo-Facorro, Benedicto (Universidad Hospital Virgen del Rocio-IBiS)

Fecha:	2022
Resumen:	People with psychosis are at higher risk of cardiovascular events, partly explained by a higher predisposition to gain weight. This has been observed in studies on individuals with a first-episode psychosis (FEP) at short and long term (mainly up to 1 year) and transversally at longer term in people with chronic schizophrenia. However, there is scarcity of data regarding longer-term (above 3-year follow-up) weight progression in FEP from longitudinal studies. The aim of this study is to evaluate the longer-term (10 years) progression of weight changes and related metabolic disturbances in people with FEP. Two hundred and nine people with FEP and 57 healthy participants (controls) were evaluated at study entry and prospectively at 10-year follow-up. Anthropometric, clinical, and sociodemographic data were collected. People with FEP presented a significant and rapid increase in mean body weight during the first year of treatment, followed by less pronounced but sustained weight gain over the study period (Δ15. 2 kg; SD 12. 3 kg). This early increment in weight predicted longer-term changes, which were significantly greater than in healthy controls (Δ2. 9 kg; SD 7. 3 kg). Weight gain correlated with alterations in lipid and glycemic variables, leading to clinical repercussion such as increments in the rates of obesity and metabolic disturbances. Sex differences were observed, with women presenting higher increments in body mass index than men. This study confirms that the first year after initiating antipsychotic treatment is the critical one for weight gain in psychosis. Besides, it provides evidence that weight gain keep progressing even in the longer term (10 years), causing relevant metabolic disturbances.
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Cholesterol ; Glucose ; Medication-naïve ; Second-generation antipsychotic ; Triglycerides ; Weight gain
Publicado en:	European psychiatry, Vol. 65 (august 2022) , ISSN 1778-3585

DOI: 10.1192/j.eurpsy.2022.2308
PMID: 35971658

10 p, 292.0 KB

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