Big data and reference intervals : rationale, current practices, harmonization and standardization prerequisites and future perspectives of indirect determination of reference intervals using routine data
Martínez Sánchez, Luisa María (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Marques-Garcia, Fernando (University Hospital of Salamanca. Department of Clinical Biochemistry)
Ozarda, Yesim (Uludag University School of Medicine. Department of Medical Biochemistry)
Blanco, Albert (Hospital Universitari Vall d'Hebron)
Brouwer, Nannette (Diagnost-IQ, Expert Centre for Clinical Chemistry)
Canalias Reverter, Francesca (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Cobbaert, Christa (Leiden University Medical Centre. Department of Clinical Chemistry and Laboratory Medicine)
Thelen, Marc (Stichting Kwaliteitsbewaking Medische Laboratoriumdiagnostiek)
den Elzen, Wendy (Leiden University Medical Centre. Department of Clinical Chemistry and Laboratory Medicine)

Date:	2020
Abstract:	Reference intervals are commonly used as a decision-making tool. In this review, we provide an overview on "big data" and reference intervals, describing the rationale, current practices including statistical methods, essential prerequisites concerning data quality, including harmonization and standardization, and future perspectives of the indirect determination of reference intervals using routine laboratory data.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Big data ; Indirect methods ; Reference intervals
Published in:	Advances in Laboratory Medicine, Vol. 2 (August 2020) , p. 9-16, ISSN 2628-491X

DOI: 10.1515/almed-2020-0034
PMID: 37359198

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