Solute carrier nutrient transporters in rheumatoid arthritis fibroblast-like synoviocytes
Torres, Alyssa (University of California)
Pedersen, Brian (San Diego Healthcare System)
Guma, Monica 1971- (Universitat Autònoma de Barcelona. Departament de Medicina)

Date:	2022
Abstract:	Metabolomic studies show that rheumatoid arthritis (RA) is associated with metabolic disruption. Metabolic changes in fibroblast-like synoviocytes (FLS) likely contribute to FLS abnormal response and strongly contribute to joint destruction. These changes often involve increased expression of nutrient transporters to meet a high demand for energy or biomolecules. The solute carrier (SLC) transporter families are nutrient transporters and serve as 'metabolic gates' for cells by mediating the transport of several different nutrients such as glucose, amino acids, vitamins, neurotransmitters, and inorganic/metal ions. In RA FLS SLC-mediated transmembrane transport was one pathway associated with different epigenetic landscape between RA and osteoarthritis (OA) FLS. These highlight that transporters from the SLC family offer unique targets for further research and offer the promise of future therapeutic targets for RA.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	FLS ; Metabolism ; Nutrients ; RA ; SLC transporters
Published in:	Frontiers in immunology, Vol. 13 (october 2022) , ISSN 1664-3224

DOI: 10.3389/fimmu.2022.984408
PMID: 36341411

9 p, 2.3 MB

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