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| Home > Articles > Published articles > Longitudinal association of dietary acid load with kidney function decline in an older adult population with metabolic syndrome |
| Home > Articles > Published articles > Longitudinal association of dietary acid load with kidney function decline in an older adult population with metabolic syndrome |
(Imperial College London) (Universitat Rovira i Virgili) (Universidad de Navarra) (Universitat de València) [...] Show all 49 authors
| Date: | 2022 |
| Abstract: | Diets high in acid load may contribute to kidney function impairment. This study aimed to investigate the association between dietary acid load and 1-year changes in glomerular filtration rate (eGFR) and urine albumin/creatinine ratio (UACR). Older adults with overweight/obesity and metabolic syndrome (mean age 65 ± 5 years, 48% women) from the PREDIMED-Plus study who had available data on eGFR (n = 5,874) or UACR (n = 3,639) at baseline and after 1 year of follow-up were included in this prospective analysis. Dietary acid load was estimated as potential renal acid load (PRAL) and net endogenous acid production (NEAP) at baseline from a food frequency questionnaire. Linear and logistic regression models were fitted to evaluate the associations between baseline tertiles of dietary acid load and kidney function outcomes. One year-changes in eGFR and UACR were set as the primary outcomes. We secondarily assessed ≥ 10% eGFR decline or ≥10% UACR increase. After multiple adjustments, individuals in the highest tertile of PRAL or NEAP showed higher one-year changes in eGFR (PRAL, β: -0. 64 ml/min/1. 73 m 2 ; 95% CI: -1. 21 to -0. 08 and NEAP, β: -0. 56 ml/min/1. 73 m 2 ; 95% CI: -1. 13 to 0. 01) compared to those in the lowest category. No associations with changes in UACR were found. Participants with higher levels of PRAL and NEAP had significantly higher odds of developing ≥10% eGFR decline (PRAL, OR: 1. 28; 95% CI: 1. 07-1. 54 and NEAP, OR: 1. 24; 95% CI: 1. 03-1. 50) and ≥10 % UACR increase (PRAL, OR: 1. 23; 95% CI: 1. 04-1. 46) compared to individuals with lower dietary acid load. Higher PRAL and NEAP were associated with worse kidney function after 1 year of follow-up as measured by eGFR and UACR markers in an older Spanish population with overweight/obesity and metabolic syndrome. |
| Grants: | Ministerio de Economía y Competitividad PI13/00673 Ministerio de Economía y Competitividad PI13/00492 Ministerio de Economía y Competitividad PI13/00272 Ministerio de Economía y Competitividad PI13/01123 Ministerio de Economía y Competitividad PI13/00462 Ministerio de Economía y Competitividad PI13/00233 Ministerio de Economía y Competitividad PI13/02184 Ministerio de Economía y Competitividad PI13/00728 Ministerio de Economía y Competitividad PI13/01090 Ministerio de Economía y Competitividad PI13/01056 Ministerio de Economía y Competitividad PI14/01722 Ministerio de Economía y Competitividad PI14/00636 Ministerio de Economía y Competitividad PI14/00618 Ministerio de Economía y Competitividad PI14/00696 Ministerio de Economía y Competitividad PI14/01206 Ministerio de Economía y Competitividad PI14/01919 Ministerio de Economía y Competitividad PI14/00853 Ministerio de Economía y Competitividad PI14/01374 Ministerio de Economía y Competitividad PI14/00972 Ministerio de Economía y Competitividad PI14/00728 Ministerio de Economía y Competitividad PI14/01471 Ministerio de Economía y Competitividad PI16/00473 Ministerio de Economía y Competitividad PI16/00662 Ministerio de Economía y Competitividad PI16/01873 Ministerio de Economía y Competitividad PI16/01094 Ministerio de Economía y Competitividad PI16/00501 Ministerio de Economía y Competitividad PI16/00533 Ministerio de Economía y Competitividad PI16/00381 Ministerio de Economía y Competitividad PI16/00366 Ministerio de Economía y Competitividad PI16/01522 Ministerio de Economía y Competitividad PI16/01120 Instituto de Salud Carlos III PI17/00764 Instituto de Salud Carlos III PI17/01183 Instituto de Salud Carlos III PI17/00855 Instituto de Salud Carlos III PI17/01347 Instituto de Salud Carlos III PI17/00525 Instituto de Salud Carlos III PI17/01827 Instituto de Salud Carlos III PI17/00532 Instituto de Salud Carlos III PI17/00215 Instituto de Salud Carlos III PI17/01441 Instituto de Salud Carlos III PI17/00508 Instituto de Salud Carlos III PI17/01732 Instituto de Salud Carlos III PI17/00926 Instituto de Salud Carlos III PI19/00957 Instituto de Salud Carlos III PI19/00386 Instituto de Salud Carlos III PI19/00309 Instituto de Salud Carlos III PI19/01032 Instituto de Salud Carlos III PI19/00576 Instituto de Salud Carlos III PI19/00017 Instituto de Salud Carlos III PI19/01226 Instituto de Salud Carlos III PI19/00781 Instituto de Salud Carlos III PI19/01560 Instituto de Salud Carlos III PI19/01332 Instituto de Salud Carlos III PI20/01802 Instituto de Salud Carlos III PI20/00138 Instituto de Salud Carlos III PI20/01532 Instituto de Salud Carlos III PI20/00456 Instituto de Salud Carlos III PI20/00339 Instituto de Salud Carlos III PI20/00557 Instituto de Salud Carlos III PI20/00886 Instituto de Salud Carlos III PI20/01158 |
| Rights: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.  |
| Language: | Anglès |
| Document: | Article ; recerca ; Versió publicada |
| Subject: | Albuminuria ; Chronic kidney disease (CKD) ; Dietary acid load ; Glomerular filtration rate (GFR) ; Kidney function ; Net endogenous acid production (NEAP) ; Potential renal acid load (PRAL) ; Renal nutrition |
| Published in: | Frontiers in nutrition, Vol. 9 (september 2022) , ISSN 2296-861X |
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