Post-COVID-19 syndrome and diabetes mellitus : a propensity-matched analysis of the International HOPE-II COVID-19 Registry
Abumayyaleh, Mohammad (Heidelberg University)
Nuñez-Gil, Ivan Javier (Universidad Complutense de Madrid)
Viana-LLamas, María C. (Hospital Universitario de Guadalajara)
Raposeiras-Roubin, Sergio (Hospital Álvaro Cunqueiro (Vigo))
Romero, Rodolfo (Hospital Universitario Getafe)
Alfonso-Rodríguez, Emilio (Hospital Universitari de Bellvitge)
Uribarri, Aitor (Hospital Universitari Vall d'Hebron)
Feltes, Gisela (Hospital Nuestra Señora de América)
Becerra-Muñoz, Víctor Manuel (Hospital Universitario Virgen de la Victoria (Màlaga, Andalusia))
Santoro, Francesco (University of Foggia)
Pepe, Martino (Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari)
Castro Mejía, Alex Fernando (Hospital General del norte de Guayaquil IESS Los Ceibos)
Signes-Costa, Jaime (Hospital Clínic Universitari (València))
Gonzalez, Adelina (Hospital Universitario Infanta Sofía (San Sebastián de los Reyes))
Marín, Francisco (Hospital Clínico Universitario Virgen de la Arrixaca (El Palmar, Múrcia))
López-País, Javier (Complexo Hospitalario Universitario de Ourense - CHUO)
Manzone, Edoardo (Hospital del Sureste)
Vazquez Cancela, Olalla (Complejo Hospitalario Universitario de Santiago de Compostela)
Paeres, Carolina Espejo (Hospital Universitario Príncipe de Asturias (Alcalá de Henares, Madrid))
Masjuan, Alvaro López (Hospital Universitario Juan Ramón Jiménez)
Velicki, Lazar (Institute of Cardiovascular Diseases Vojvodina)
Weiß, Christel (Department for Statistical Analysis, University Heidelberg)
Chipayo, David (Universidad Complutense de Madrid)
Fernandez-Ortiz, Antonio (Hospital Clínico San Carlos (Madrid))
El-Battrawy, Ibrahim (Department of Cardiology and Angiology, Ruhr University of Bochum)
Akin, Ibrahim (European Center for AngioScience (ECAS))
Universitat Autònoma de Barcelona

Date:	2023
Abstract:	Diabetes mellitus (DM) is one of the most frequent comorbidities in patients suffering from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with a higher rate of severe course of coronavirus disease (COVID-19). However, data about post-COVID-19 syndrome (PCS) in patients with DM are limited. This multicenter, propensity score-matched study compared long-term follow-up data about cardiovascular, neuropsychiatric, respiratory, gastrointestinal, and other symptoms in 8,719 patients with DM to those without DM. The 1:1 propensity score matching (PSM) according to age and sex resulted in 1,548 matched pairs. Diabetics and nondiabetics had a mean age of 72. 6 ± 12. 7 years old. At follow-up, cardiovascular symptoms such as dyspnea and increased resting heart rate occurred less in patients with DM (13. 2% vs. 16. 4%; p = 0. 01) than those without DM (2. 8% vs. 5. 6%; p = 0. 05), respectively. The incidence of newly diagnosed arterial hypertension was slightly lower in DM patients as compared to non-DM patients (0. 5% vs. 1. 6%; p = 0. 18). Abnormal spirometry was observed more in patients with DM than those without DM (18. 8% vs. 13; p = 0. 24). Paranoia was diagnosed more frequently in patients with DM than in non-DM patients at follow-up time (4% vs. 1. 2%; p = 0. 009). The incidence of newly diagnosed renal insufficiency was higher in patients suffering from DM as compared to patients without DM (4. 8% vs. 2. 6%; p = 0. 09). The rate of readmission was comparable in patients with and without DM (19. 7% vs. 18. 3%; p = 0. 61). The reinfection rate with COVID-19 was comparable in both groups (2. 9% in diabetics vs. 2. 3% in nondiabetics; p = 0. 55). Long-term mortality was higher in DM patients than in non-DM patients (33. 9% vs. 29. 1%; p = 0. 005). The mortality rate was higher in patients with DM type II as compared to those without DM. Readmission and reinfection rates with COVID-19 were comparable in both groups. The incidence of cardiovascular symptoms was higher in patients without DM.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Diabetes mellitus ; Post-covid-19 syndrome ; SARS-CoV-2 ; Respiratory complications ; Reinfection ; Vaccination rate ; Long-term mortality
Published in:	Frontiers in endocrinology, Vol. 14 (may 2023) , ISSN 1664-2392

DOI: 10.3389/fendo.2023.1167087
PMID: 37260447

12 p, 682.4 KB

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