Conditioning by a previous experience impairs the rewarding value of a comfort meal
Nieto Ruiz, Adoración (Hospital Universitari Vall d'Hebron)
Livovsky, Dan M. (Digestive Diseases Institute, Shaare Zedek Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 9103102, Israel)
Azpiroz Vidaur, Fernando (Universitat Autònoma de Barcelona. Departament de Medicina)

Date:	2023
Abstract:	Background. Meal ingestion induces a postprandial experience that involves homeostatic and hedonic sensations. Our aim was to determine the effect of aversive conditioning on the postprandial reward of a comfort meal. Methods: A sham-controlled, randomised, parallel, single-blind study was performed on 12 healthy women (6 per group). A comfort meal was tested before and after coupling the meal with an aversive sensation (conditioning intervention), induced by infusion of lipids via a thin naso-duodenal catheter; in the pre- and post-conditioning tests and in the control group, a sham infusion was performed. Participants were instructed that two recipes of a tasty humus would be tested; however, the same meal was administered with a colour additive in the conditioning and post-conditioning tests. Digestive well-being (primary outcome) was measured every 10 min before and 60 min after ingestion using graded scales. Results: In the aversive conditioning group, the comfort meal in the pre-conditioning test induced a pleasant postprandial experience, which was significantly lower in the post-conditioning test; the effect of aversive conditioning (change from pre- to post-conditioning) was significant as compared to sham conditioning in the control group, which showed no differences between study days. Conclusion: The hedonic postprandial response to a comfort meal in healthy women is impaired by aversive conditioning. ClinicalTrials. gov ID: NCT04938934.
Grants:	Ministerio de Ciencia e Innovación PID2021-122295OB-I00
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Pavlovian conditioning ; Aversive conditioning ; Eating behaviour ; Digestive sensations ; Postprandial symptoms ; Digestive well-being ; Food valence
Published in:	Nutrients, Vol. 15 (may 2023) , ISSN 2072-6643
Related work:	Granero, Roser, ed.; Fernández-Aranda, Fernando, ed.; Jiménez-Murcia, Susana, ed. Eating disorders and addictive behaviors : implications for human health. Basel: MDPI, 2024. viii, 204 pàg. ISBN 978-3-7258-0575-4 https://doi.org/10.3390/books978-3-7258-0576-1

Compilat a: https://ddd.uab.cat/record/290735
DOI: 10.3390/nu15102247
PMID: 37242129

13 p, 1.2 MB

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