Exposures to pesticides and risk of cancer : Evaluation of recent epidemiological evidence in humans and paths forward
Cavalier, Haleigh (Department of Population Health. New York University)
Trasande, Leonardo (NYU School of Global Public Health)
Porta, Miquel 1957- (Universitat Autònoma de Barcelona)

Fecha:	2023
Resumen:	Knowledge of the role in cancer etiology of environmental exposures as pesticides is a prerequisite for primary prevention. We review 63 epidemiological studies on exposure to pesticides and cancer risk in humans published from 2017 to 2021, with emphasis on new findings, methodological approaches, and gaps in the existing literature. While much of the recent evidence suggests causal relationships between pesticide exposure and cancer, the strongest evidence exists for acute myeloid leukemia (AML) and colorectal cancer (CRC), diseases in which the observed associations were consistent across several studies, including high-quality prospective studies and those using biomarkers for exposure assessment, with some observing dose-response relationships. Though high-quality studies have been published since the IARC monograph on organophosphate insecticides in 2017, there are still gaps in the literature on carcinogenic evidence in humans for a large number of pesticides. To further knowledge, we suggest leveraging new techniques and methods to increase sensitivity and precision of exposure assessment, incorporate multi-omics data, and investigate more thoroughly exposure to chemical mixtures. There is also a strong need for better and larger population-based cohort studies that include younger and nonoccupationally exposed individuals, particularly during developmental periods of susceptibility. Though the existing evidence has limitations, as always in science, there is sufficient evidence to implement policies and regulatory action that limit pesticide exposure in humans and, hence, further prevent a significant burden of cancers.
Ayudas:	Fundació la Marató de TV3 15072020 Fundació la Marató de TV3 20132910 Instituto de Salud Carlos III PI17/00088 Instituto de Salud Carlos III PI21/00052
Nota:	Altres ajuts: acords transformatius de la UAB
Nota:	The work was supported in part by research grants from the National Institutes of Health (P30ES000260); Instituto de Salud Carlos III - FEDER, Ministry of Health, Government of Spain (FIS PI17/00088, FIS PI21/00052 and CIBER de Epidemiología y Salud Pública - CIBERESP); the Hospital del Mar Medical Research Institute (IMIM), Barcelona; Fundació La Marató de TV3 (20132910); the CRUE-Santander Fondo Supera Covid-19 (15072020); and the Government of Catalonia (2017 SGR 439). The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH or other institutions.
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Publicado en:	International Journal of Cancer, Vol. 152 Núm. 5 (january 2023) , p. 879-912, ISSN 1097-0215

DOI: 10.1002/ijc.34300
PMID: 36134639

34 p, 1.9 MB

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