Genome-Wide Association Studies of Coffee Intake in UK/US Participants of European Ancestry Uncover Gene-Cohort Influences
Thorpe, Hayley H A (University of Guelph)
Fontanillas, Pierre (23andMe, Inc.)
Pham, Benjamin K (University of California San Diego La Jolla, CA, USA)
Meredith, John J (University of California San Diego)
Jennings, Mariela V (University of California San Diego)
Courchesne-Krak, Natasia S (University of California San Diego)
Vilar-Ribó, L (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Bianchi, Sevim B (University of California San Diego)
Mutz, Julian (King's College London)
Elson, Sarah L (University of Guelph)
Khokhar, Jibran Y (University of Guelph)
Abdellaoui, Abdel (University of Amsterdam)
Davis, Lea K (Vanderbilt University Medical Center)
Palmer, Abraham A (University of California San Diego)
Sanchez-Roige, Sandra (Vanderbilt University Medical Center)
Universitat Autònoma de Barcelona

Fecha:	2023
Resumen:	Coffee is one of the most widely consumed beverages. We performed a genome-wide association study (GWAS) of coffee intake in US-based 23andMe participants (N =130,153) and identified 7 significant loci, with many replicating in three multi-ancestral cohorts. We examined genetic correlations and performed a phenome-wide association study across thousands of biomarkers and health and lifestyle traits, then compared our results to the largest available GWAS of coffee intake from UK Biobank (UKB; N =334,659). The results of these two GWAS were highly discrepant. We observed positive genetic correlations between coffee intake and psychiatric illnesses, pain, and gastrointestinal traits in 23andMe that were absent or negative in UKB. Genetic correlations with cognition were negative in 23andMe but positive in UKB. The only consistent observations were positive genetic correlations with substance use and obesity. Our study shows that GWAS in different cohorts could capture cultural differences in the relationship between behavior and genetics.
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució i la comunicació pública de l'obra, sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Publicado en:	medRxiv, september 2023

DOI: 10.1101/2023.09.09.23295284
PMID: 37745582

57 p, 12.2 MB

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