Investigating the impact of physical activity on mitochondrial function in Parkinson's disease (PARKEX) : Study protocol for A randomized controlled clinical trial
Magaña, Juan Carlos (Universitat Ramon Llull)
Deus, Cláudia Maria (University of Coimbra)
Baldellou, Laura (Universitat Ramon Llull)
Avellanet, Merce (Universitat d'Andorra)
Gea-Rodríguez, Elvira (Universitat d'Andorra)
Enriquez-Calzada, Silvia (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Laguna, Ariadna (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Martinez-Vicente, Marta (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Hernández-Vara, Jorge (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Giné-Garriga, Maria (Universitat Ramon Llull)
Pereira, Susana Patricia (University of Porto)
Montane, Joel (Universitat Ramon Llull)
Universitat Autònoma de Barcelona

Fecha:	2023
Resumen:	Parkinson's disease (PD) is characterized by the progressive dopaminergic neuron degeneration, resulting in striatal dopamine deficiency. Mitochondrial dysfunction and oxidative stress are associated with PD pathogenesis. Physical activity (PA) has been shown to ameliorate neurological impairments and to impede age-related neuronal loss. In addition, skin fibroblasts have been identified as surrogate indicators of pathogenic processes correlating with clinical measures. The PARKEX study aims to compare the effects of two different PA programs, analyzing the impact on mitochondrial function in patients' skin fibroblasts as biomarkers for disease status and metabolic improvement. Early-stage PD patients (n = 24, H&Y stage I to III) will be randomized into three age- and sex-matched groups. Group 1 (n = 8) will undergo basic physical training (BPT) emphasizing strength and resistance. Group 2 (n = 8) will undergo BPT combined with functional exercises (BPTFE), targeting the sensorimotor pathways that are most affected in PD (proprioception-balance-coordination) together with cognitive and motor training (Dual task training). Group 3 (n = 8) will serve as control (sedentary group; Sed). Participants will perform three sessions per week for 12 weeks. Assessment of motor function, quality of life, sleep quality, cognitive aspects and humor will be conducted pre- and post-intervention. Patient skin fibroblasts will be collected before and after the intervention and characterized in terms of metabolic remodeling and mitochondrial bioenergetics. Ethical approval has been given to commence this study. This trial is registered at clinicaltrials. gov (NCT05963425). Trial registration. .
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Publicado en:	PloS one, Vol. 18 (november 2023) , ISSN 1932-6203

DOI: 10.1371/journal.pone.0293774
PMID: 37992028

13 p, 1.1 MB

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