Plasma concentration of leptin is related to food addiction in gambling disorder : clinical and neuropsychological implications
Etxandi, Mikel (Hospital Universitari de Bellvitge)
Baenas Soto, Isabel Maria (Hospital Universitari de Bellvitge)
Mora-Maltas, Bernat (Hospital Universitari de Bellvitge)
Granero, Roser (Institut d'Investigació Biomèdica de Bellvitge)
Fernández-Aranda, Fernando (Hospital Universitari de Bellvitge)
Tovar, Sulay (Instituto de Salud Carlos III)
Solé-Morata, Neus (Hospital Universitari de Bellvitge)
Lucas, Ignacio (Hospital Universitari de Bellvitge)
Casado, Sabela (Instituto de Salud Carlos III)
Gomez-Peña, Mónica (Hospital Universitari de Bellvitge)
Moragas, Laura (Hospital Universitari de Bellvitge)
Del Pino-Gutiérrez, Amparo (Instituto de Salud Carlos III)
Tapia, Javier (Hospital Universitari de Bellvitge)
Valenciano-Mendoza, Eduardo (Hospital Universitari de Bellvitge)
Potenza, Marc N. (Yale University School of Medicine)
Gearhardt, Ashley N (University of Michigan Herbarium)
Dieguez, Carlos (Instituto de Salud Carlos III)
Jiménez-Murcia, Susana (Universitat Autònoma de Barcelona. Departament de Psicobiologia i de Metodologia de Ciències de la Salut)

Fecha:	2023
Descripción:	13 pàg.
Resumen:	BACKGROUND: Data implicate overlaps in neurobiological pathways involved in appetite regulation and addictive disorders. Despite different neuroendocrine measures having been associated with both gambling disorder (GD) and food addiction (FA), how appetite-regulating hormones may relate to the co-occurrence of both entities remain incompletely understood. AIMS: To compare plasma concentrations of ghrelin, leptin, adiponectin, and liver-expressed antimicrobial peptide 2 (LEAP-2) between patients with GD, with and without FA, and to explore the association between circulating hormonal concentrations and neuropsychological and clinical features in individuals with GD and FA. METHODS: The sample included 297 patients diagnosed with GD (93. 6% males). None of the patients with GD had lifetime diagnosis of an eating disorder. FA was evaluated with the Yale Food Addiction Scale 2. 0. All patients were assessed through a semi-structured clinical interview and a psychometric battery including neuropsychological tasks. Blood samples to measure hormonal variables and anthropometric variables were also collected. RESULTS: From the total sample, FA was observed in 23 participants (FA+) (7. 7% of the sample, 87% males). When compared participants with and without FA, those with FA+ presented both higher body mass index (BMI) (p < 0. 001) and leptin concentrations, after adjusting for BMI (p = 0. 013). In patients with FA, leptin concentrations positively correlated with impulsivity, poorer cognitive flexibility, and poorer inhibitory control. Other endocrine measures did not differ between groups. DISCUSSION AND CONCLUSIONS: The present study implicates leptin in co-occurring GD and FA. Among these patients, leptin concentration has been associated with clinical and neuropsychological features, such as impulsivity and cognitive performance in certain domains.
Ayudas:	European Commission 847879 Instituto de Salud Carlos III PI20/00132 Agencia Estatal de Investigación PID2021-124887OB-I00 Agència de Gestió d'Ajuts Universitaris i de Recerca SGR/2021-00824
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Addictive behaviors ; Food addiction ; Gambling disorder ; Impulsivity ; Leptin
Publicado en:	Journal of behavioral addictions, Vol. 12 Núm. 4 (2023) , p. 1019-1031, ISSN 2063-5303

DOI: 10.1556/2006.2023.00051
PMID: 38141066

13 p, 1.7 MB

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