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| Home > Articles > Published articles > Modular Drug-Loaded Nanocapsules with Metal Dome Layers as a Platform for Obtaining Synergistic Therapeutic Biological Activities |
| Home > Articles > Published articles > Modular Drug-Loaded Nanocapsules with Metal Dome Layers as a Platform for Obtaining Synergistic Therapeutic Biological Activities |
(The Hebrew University of Jerusalem) (Institut Català de Nanociència i Nanotecnologia) (Institut Català de Nanociència i Nanotecnologia) (The Hebrew University of Jerusalem) (Institut Català de Nanociència i Nanotecnologia)
| Date: | 2023 |
| Abstract: | Multifunctional drug-loaded polymer-metal nanocapsules have attracted increasing attention in drug delivery due to their multifunctional potential endowed by drug activity and response to physicochemical stimuli. Current chemical synthesis methods of polymer/metal capsules require specific optimization of the different components to produce particles with precise properties, being particularly complex for Janus structures combining polymers and ferromagnetic and highly reactive metals. With the aim to generate tunable synergistic nanotherapeutic actuation with enhanced drug effects, here we demonstrate a versatile hybrid chemical/physical fabrication strategy to incorporate different functional metals with tailored magnetic, optical, or chemical properties on solid drug-loaded polymer nanoparticles. As archetypical examples, we present poly(lactic- co -glycolic acid) (PLGA) nanoparticles (diameters 100-150 nm) loaded with paclitaxel, indocyanine green, or erythromycin that are half-capped by either Fe, Au, or Cu layers, respectively, with application in three biomedical models. The Fe coating on paclitaxel-loaded nanocapsules permitted efficient magnetic enhancement of the cancer spheroid assembly, with 40% reduction of the cross-section area after 24 h, as well as a higher paclitaxel effect. In addition, the Fe-PLGA nanocapsules enabled external contactless manipulation of multicellular cancer spheroids with a speed of 150 μm/s. The Au-coated and indocyanine green-loaded nanocapsules demonstrated theranostic potential and enhanced anticancer activity in vitro and in vivo due to noninvasive fluorescence imaging with long penetration near-infrared (NIR) light and simultaneous photothermal-photodynamic actuation, showing a 3. 5-fold reduction in the tumor volume growth with only 5 min of NIR illumination. Finally, the Cu-coated erythromycin-loaded nanocapsules exhibited enhanced antibacterial activity with a 2. 5-fold reduction in the MIC50 concentration with respect to the free or encapsulated drug. Altogether, this technology can extend a nearly unlimited combination of metals, polymers, and drugs, thus enabling the integration of magnetic, optical, and electrochemical properties in drug-loaded nanoparticles to externally control and improve a wide range of biomedical applications. |
| Grants: | Agència de Gestió d'Ajuts Universitaris i de Recerca 2017/SGR-292 Agència de Gestió d'Ajuts Universitaris i de Recerca 2021/SGR-0065 Agencia Estatal de Investigación RYC2019-027449 Agencia Estatal de Investigación RTI2018-095495-J-I00 Agencia Estatal de Investigación PID2019-106229RB-I00 Agencia Estatal de Investigación PDC2022-133036-I00 Agencia Estatal de Investigación PCIN2016-093 Agencia Estatal de Investigación MAT2016-77391-R European Commission 756762 |
| Note: | Altres ajuts: the Fundación Ramón Areces CIVP19A5922 |
| Rights: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.  |
| Language: | Anglès |
| Document: | Article ; recerca ; Versió publicada |
| Subject: | Drug delivery ; Nanocapsules ; Multifunctional nanocapsules ; Janus metal-polymer nanocapsules |
| Published in: | ACS applied materials & interfaces, Vol. 15, Issue 43 (October 2023) , p. 50330-50343, ISSN 1944-8252 |
