Learning deficits in an odor reward-task induced by parafascicular thalamic lesions are ameliorated by pretraining d-cycloserine in the prelimbic cortex
Villarejo-Rodríguez, Irene (Universitat Autònoma de Barcelona. Departament de Psicobiologia i de Metodologia de Ciències de la Salut)
Portero Tresserra, Marta (Universitat Autònoma de Barcelona. Departament de Psicobiologia i de Metodologia de Ciències de la Salut)
Vale Martínez, Anna (Universitat Autònoma de Barcelona. Departament de Psicobiologia i de Metodologia de Ciències de la Salut)
Martí Nicolovius, Margarita (Universitat Autònoma de Barcelona. Departament de Psicobiologia i de Metodologia de Ciències de la Salut)
Guillazo i Blanch, Gemma (Universitat Autònoma de Barcelona. Departament de Psicobiologia i de Metodologia de Ciències de la Salut)
Boadas Vaello, Pere (Universitat Autònoma de Barcelona. Departament de Psicobiologia i de Metodologia de Ciències de la Salut)

Date:	2013
Abstract:	We investigated whether the N-methyl- d-aspartate (NMDA) receptor partial agonist d-cycloserine (DCS) infused into the prelimbic cortex (PLC) would reverse the learning deficits caused by bilateral excitotoxic lesions of the parafascicular nucleus (PFn) in an odor discrimination task (ODT). Rats with PFn lesions received a bilateral infusion of DCS (10 μg/side) into the PLC 20. min before ODT acquisition. The task retention was evaluated in a drug-free test carried out 24. h later. DCS significantly attenuated the PFn lesion-induced deficits as measured by both latency to nose-poke the rewarded odor and number of errors committed during ODT acquisition and retention. Therefore, DCS may be an enhancing memory treatment in animal models of cognitive impairment, such as PFn-lesioned rats. The PFn contribution to learning and memory may possibly be linked to its role in the modulation of glutamatergic PLC activity. © 2012 Elsevier B. V.
Note:	This research was supported by funds provided by the Ministerio de Ciencia e Innovación (PSI2008-0426, IVR: BES-2006-14056) and Juan de la Cierva Grant (JCI-2008-2168). The authors wish to thank Gerald-Patrick Fannon for revising the manuscript.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Language:	Anglès
Document:	Article ; recerca ; Versió acceptada per publicar
Subject:	Glutamate ; Intralaminar nuclei ; NMDA receptors ; Odor learning ; Prefrontal cortex ; Thalamus
Published in:	Behavioural Brain Research, Vol. 238 (2013) , p. 289-292, ISSN 1872-7549

DOI: 10.1016/j.bbr.2012.10.041

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