000288282 001 __ 288282
000288282 005 __ 20240505184203.0
000288282 024 7_ $2 doi $a 10.3390/genes14101941
000288282 024 8_ $9 artpubuab $9 scholar $9 driver $a oai:ddd.uab.cat:288282
000288282 035 __ $9 pmcid $a PMC10606707
000288282 035 __ $9 pmc-uid $a 10606707
000288282 035 __ $9 pmid $a 37895290
000288282 035 __ $a oai:pubmedcentral.nih.gov:10606707
000288282 035 __ $a oai:egreta.uab.cat:publications/588031ba-650f-41b4-9b20-b75676714c74
000288282 041 __ $a eng
000288282 100 10 $a Hervás Rivero, Carlos $u Universidad de Zaragoza. Instituto Agroalimentario de Aragón
000288282 245 10 $a Genomic Scanning of Inbreeding Depression for Litter Size in Two Varieties of Iberian Pigs
000288282 251 __ $1 http://purl.org/coar/version/c_970fb48d4fbd8a85 $2 openaire4 $9 VoR $a Versió publicada
000288282 260 __ $c 2023
000288282 520 3_ $a Inbreeding depression is expected to be more pronounced in fitness-related traits, such as pig litter size. Recent studies have suggested that the genetic determinism of inbreeding depression may be heterogeneous across the genome. Therefore, the objective of this study was to conduct a genomic scan of the whole pig autosomal genome to detect the genomic regions that control inbreeding depression for litter size in two varieties of Iberian pigs (Entrepelado and Retinto). The datasets consisted of 2069 (338 sows) and 2028 (327 sows) records of litter size (Total Number Born and Number Born Alive) for the Entrepelado and Retinto varieties. All sows were genotyped using the Geneseek GGP PorcineHD 70 K chip. We employed the Unfavorable Haplotype Finder software to extract runs of homozygosity (ROHs) and conducted a mixed-model analysis to identify highly significant differences between homozygous and heterozygous sows for each specific ROH. A total of eight genomic regions located on SSC2, SSC5, SSC7, SSC8, and SSC13 were significantly associated with inbreeding depression, housing some relevant genes such as FSHR, LHCGR, CORIN, AQP6, and CEP120.
000288282 536 __ $a Ministerio de Ciencia e Innovación $d https://doi.org/10.13039/501100004837 $f CGL2016-80155-R
000288282 536 __ $a Ministerio de Ciencia e Innovación $d https://doi.org/10.13039/501100004837 $f PID2020-114705RB-I00
000288282 536 __ $a European Commission. Horizon 2020 $d https://doi.org/10.13039/501100007601 $f 801586
000288282 540 __ $9 open access $a Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. $u https://creativecommons.org/licenses/by/4.0/
000288282 546 __ $a Anglès
000288282 599 __ $a recerca
000288282 653 1_ $a Iberian pig
000288282 653 1_ $a Litter size
000288282 653 1_ $a Inbreeding depression
000288282 655 _7 $1 http://purl.org/coar/resource_type/c_6501 $2 openaire4 $a Article $c literature
000288282 700 10 $0 0000-0002-9249-3070 $a Srihi, Houssemeddine $u Universidad de Zaragoza. Instituto Agroalimentario de Aragón
000288282 700 10 $0 0000-0003-0964-9212 $a López Carbonell, David $u Universidad de Zaragoza. Instituto Agroalimentario de Aragón
000288282 700 10 $0 0000-0002-4982-3556 $a Casellas Vidal, Joaquim $u Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments
000288282 700 10 $0 0000-0002-6221-3576 $a Ibañez-Escriche, Noelia $u Universitat Politècnica de València. Instituto Universitario de Ciencia y Tecnología Animal
000288282 700 10 $a Negro, Sara $u INGA FOOD S.A. Programa de Mejora Genética "Castua"
000288282 700 10 $0 0000-0001-6256-5478 $a Varona, Luis $u Universidad de Zaragoza. Instituto Agroalimentario de Aragón
000288282 773 __ $g Vol. 14 (october 2023) $t Genes $x 2073-4425
000288282 856 40 $p 11 $s 2857690 $u https://ddd.uab.cat/pub/artpub/2023/pmc_10606707/pmc_10606707.pdf
000288282 973 __ $m 10 $v 14 $x genes_a2023m10v14 $y 2023
000288282 980 __ $a ARTPUB $b UAB