COPD : systemic proteomic profiles in frequent and infrequent exacerbators
Enríquez-Rodríguez, César Jessé (Hospital del Mar (Barcelona, Catalunya))
Casadevall, Carme (Hospital del Mar (Barcelona, Catalunya))
Faner, Rosa (Hospital Clínic i Provincial de Barcelona)
Castro-Costa, Ady (Hospital 12 de Octubre (Madrid))
Pascual-Guàrdia, Sergi (Hospital del Mar (Barcelona, Catalunya))
Seijó, Luis (Universidad Autónoma de Madrid)
López-Campos, José Luis (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia))
Peces-Barba, Germán (Universidad Autónoma de Madrid)
Monsó, Eduard (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Barreiro, Esther (Hospital del Mar (Barcelona, Catalunya))
Cosio, Borja G (Universitat de les Illes Balears)
Agustí García-Navarro, Àlvar (Hospital Clínic i Provincial de Barcelona)
Gea, Joaquim (Hospital del Mar (Barcelona, Catalunya))
Universitat Autònoma de Barcelona

Fecha:	2024
Resumen:	Some patients with COPD suffer frequent exacerbations (FE). We hypothesised that their systemic proteomic profile would be different from that of non-frequent exacerbators (NFE). The objective of the present study was to contrast the systemic proteomic profile in FE versus NFE. As a reference, we also determined the systemic proteomic profile of healthy controls (HC) and COPD patients during an actual episode of exacerbation (AE). In the analysis we included 40 clinically stable COPD patients (20 FE and 20 NFE), and 20 HC and 10 AE patients. Their plasma samples were analysed by combining two complementary proteomic approaches: label-free liquid chromatography-tandem mass spectrometry and multiplex immunoassays. Gene Ontology annotation, pathway enrichment and network analyses were used to investigate molecular pathways associated with differentially abundant proteins/peptides (DAPs). Compared with HC, we identified 40 DAPs in FE, 10 in NFE and 63 in AE. Also compared to HC, pathway functional and protein-protein network analyses revealed dysregulation of inflammatory responses involving innate and antibody-mediated immunity in COPD, particularly in the FE group, as well as during an AE episode. Besides, we only identified alterations in the complement and coagulation cascades in AE. There are specific plasma proteome profiles associated with FE, which are partially shared with findings observed during AE, albeit others are uniquely present during the actual episode of AE. Although COPD exacerbations are characterised by a specific plasma proteomic profile, those patients who suffer frequent acute episodes maintain some of these abnormalities, providing a possible biological basis for this phenotype.
Ayudas:	Ministerio de Sanidad y Consumo CB06/06/0043 Instituto de Salud Carlos III PI21/00785 Ministerio de Economía y Competitividad SAF2014-54371-R
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Publicado en:	ERJ Open Research, Vol. 10 (march 2024) , ISSN 2312-0541

DOI: 10.1183/23120541.00004-2024
PMID: 38529348

14 p, 1.8 MB

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Documentos de investigación > Documentos de los grupos de investigación de la UAB > Centros y grupos de investigación (producción científica) > Ciencias de la salud y biociencias > Instituto de Investigación e Innovación Parc Taulí (I3PT)
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