Previous fracture and subsequent fracture risk : a meta-analysis to update FRAX
Kanis, John A. (Centre for Metabolic Bone Diseases. University of Sheffield (Austràlia))
Johansson, Helena (University of Gothenburg (Austràlia))
McCloskey, Eugene V. (University of Sheffield (Austràlia))
Liu, Enwu (Mary Australian Catholic University (Austràlia))
Åkesson, Kristina Eva (Skåne University Hospital (Suècia))
Anderson, Frederick A. (University of Massachusetts Medical School (Regne Unit))
Azagra Ledesma, Rafael (Universitat Autònoma de Barcelona. Departament de Medicina)
Bager, Cecilie Liv (Nordic Bioscience A/S (Dinamarca))
Beaudart, Charlotte H. (University of Maastricht (Bèlgica))
Bischoff-Ferrari, Heike Annette (University of Zurich and City Hospital (Suïssa))
Biver, Emmanuel (University of Geneva (Suïssa))
Bruyère, Olivier (University of Liège (Bèlgica))
Cauley, Jane A. (University of Pittsburgh (Estats Units d'Amèrica))
Center, Jacqueline (University of Notre Dame Australia (Austràlia))
Chapurlat, Roland (Université Claude Bernard-Lyon1 (França))
Christiansen, Clause Bohn (Nordic Bioscience A/S (Dinamarca))
Cooper, Cyrus C. (University of Oxford (Regne Unit))
Crandall, Carolyn J. (University of California (Estats Units d'Amèrica))
Cummings, Steven Ron (California Pacific Medical Center Research Institute (Estats units d'Amèrica))
da Silva, José António Pereira (Centro Hospitalar e Universitário de Coimbra (Portugal))
Dawson-Hughes, Bess (Tufts University (Estats Units d'Amèrica))
Díez Pérez, Adolfo (Hospital del Mar (Barcelona, Catalunya))
Dufour, Alyssa B. (Harvard Medical School)
Eisman, John A. (University of Notre Dame Australia (Austràlia))
Elders, Petra (Amsterdam Public Health Research Institute (Països Baixos))
Ferrari, Serge Livio (University of Geneva (Suïssa))
Fujita, Yuki (Kindai University Faculty of Medicine (Japó))
Fujiwara, Saeko (Yasuda Women's University (Japó))
Glüer, Claus Christian (University Medical Center Schleswig-Holstein Kiel (Alemanya))
Goldshtein, Inbal (Tel Aviv University)
Goltzman, David (McGill University Health Centre (Canadà))
Gudnason, V. G. (University of Iceland (Islàndia))
Hall, Jill (University of Edinburgh)
Hans, Didier B. (University of Lausanne (Suïssa))
Hoff, Mari (St Olavs Hospital (Noruega))
Hollick, Rosemary Jane (University of Aberdeen (Regne Unit))
Huisman, Martijn A. (Vrije University (Països Baixos))
Iki, Masayuki (Kindai University Faculty of Medicine (Japó))
Ish-Shalom, Sophia (Elisha Hospital (Israel))
Jones, Graeme D. (University of Tasmania (Austràlia))
Karlsson, Magnus Karl (Skåne University Hospital (Suècia))
Khosla, Sundeep (Mayo Clinic (Rochester, Estats Units d'Amèrica))
Kiel, Douglas P. (Beth Israel Deaconess Cancer Center (Boston, Estats Units d'Amèrica))
Koh, Woonpuay (Agency for Science Technology and Research (Singapur))
Koromani, Fjorda (Erasmus University Medical Center (Països Baixos))
Kotowicz, Mark (The University of Melbourne (Austràlia))
Kröger, Heikki P. J. (University of Eastern Finland (Finlàndia))
Kwok, Timothy Chi Yui (Lausanne University Hospital (Hong Kong))
Langhammer, Arnulf (Norwegian University of Science and Technology (Noruega))
Larijani, Bagher (Tehran University of Medical Sciences (Iran))
Lippuner, Kurt (University of Bern (Suïssa))
Mellström, Dan D. (Sahlgrenska University Hospital Mölndal (Suècia))
Merlijn, Thomas (Amsterdam Public Health Research Institute (Països Baixos))
Nordström, Anna (Uppsala University (Suècia))
Nordström, Peter (Uppsala University (Suècia))
O'Neill, Terence W. (University of Manchester (regne Unit))
Obermayer-Pietsch, Barbara Maria (Center for Biomarker Research in Medicine (Àustria))
Ohlsson, Claes (Region Västra Götaland (Suècia))
Orwoll, Eric (Oregon Health and Science University (Estats Units d'Amèerica))
Pasco, Julie A. (Monash University (Austràlia))
Rivadeneira, Fernando F. (Erasmus University Medical Center (Països Baixos))
Schott, Anne Marie (Université Claude Bernard Lyon 1. U INSERM 1290 RESHAPE (França))
Shiroma, Eric J. (National Institute on Aging (Estats Units d'Amèrica))
Siggeirsdottir, Kristín (Janus Rehabilitation (Islàndia))
Simonsick, Eleanor Marie (National Institute on Aging Intramural Research Program (Estats Units d'Amèrica))
Sornay-Rendu, Elisabeth (Hôpital Edouard Herriot (França))
Sund, Reijo (University of Eastern Finland (Finlàndia))
Swart, Karin M. A. (PHARMO Institute for Drug Outcomes Research (Països Baixos))
Szulc, Pawel (Hôpital Edouard Herriot (França))
Tamaki, Jyunko (Educational Foundation of Osaka Medical and Pharmaceutical University(Japó))
Torgerson, David J. (University of York (Regne Unit))
van Schoor, Natasja (Amsterdam University Medical Center (UMC))
van Staa, Tjeerd Pieter (University of Manchester (Regne Unit))
Vila-Domènech, Joan Salvador (Hospital del Mar (Barcelona, Catalunya))
Wareham, Nicholas J. (University of Cambridge (Regne Unit))
Wright, Nicole (University of Alabama at Birmingham (Estats Units d'Amèrica))
Yoshimura, Noriko (The University of Tokyo Hospital (Japó))
Zillikens, M. Carola (Erasmus University Medical Center (Països Baixos))
Zwart, Marta (Institut Universitari d'Investigació en Atenció Primària Jordi Gol)
Vandenput, Liesbeth (University of Gothenburg (Suècia))
Harvey, Nicholas C. (University of Southampton and University Hospitals Southampton NHS Foundation Trust (Regne Unit))
Lorentzon, Mattias (SahlgUniversity of Gothenburg (Suècia))
Leslie, William D. (University of Manitoba (Canadà))

Fecha:	2023
Resumen:	A large international meta-analysis using primary data from 64 cohorts has quantified the increased risk of fracture associated with a previous history of fracture for future use in FRAX. The aim of this study was to quantify the fracture risk associated with a prior fracture on an international basis and to explore the relationship of this risk with age, sex, time since baseline and bone mineral density (BMD). We studied 665,971 men and 1,438,535 women from 64 cohorts in 32 countries followed for a total of 19. 5 million person-years. The effect of a prior history of fracture on the risk of any clinical fracture, any osteoporotic fracture, major osteoporotic fracture, and hip fracture alone was examined using an extended Poisson model in each cohort. Covariates examined were age, sex, BMD, and duration of follow-up. The results of the different studies were merged by using the weighted β-coefficients. A previous fracture history, compared with individuals without a prior fracture, was associated with a significantly increased risk of any clinical fracture (hazard ratio, HR = 1. 88; 95% CI = 1. 72-2. 07). The risk ratio was similar for the outcome of osteoporotic fracture (HR = 1. 87; 95% CI = 1. 69-2. 07), major osteoporotic fracture (HR = 1. 83; 95% CI = 1. 63-2. 06), or for hip fracture (HR = 1. 82; 95% CI = 1. 62-2. 06). There was no significant difference in risk ratio between men and women. Subsequent fracture risk was marginally downward adjusted when account was taken of BMD. Low BMD explained a minority of the risk for any clinical fracture (14%), osteoporotic fracture (17%), and for hip fracture (33%). The risk ratio for all fracture outcomes related to prior fracture decreased significantly with adjustment for age and time since baseline examination. A previous history of fracture confers an increased risk of fracture of substantial importance beyond that explained by BMD. The effect is similar in men and women. Its quantitation on an international basis permits the more accurate use of this risk factor in case finding strategies.
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Hip fracture ; Major osteoporotic fracture ; Meta-analysis ; Osteoporotic fracture ; Prior fracture
Publicado en:	Osteoporosis International, Vol. 34 Núm. 12 (december 2023) , p. 2027-2045, ISSN 1433-2965

DOI: 10.1007/s00198-023-06870-z
PMID: 37566158

32 p, 989.5 KB

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