Pituitary Apoplexy : Risk Factors and Underlying Molecular Mechanisms
Biagetti, Betina (Vall d'Hebron Institut de Recerca (VHIR))
Simó Canonge, Rafael (Vall d'Hebron Institut de Recerca (VHIR))
Universitat Autònoma de Barcelona

Date:	2022
Abstract:	Pituitary apoplexy is a rare syndrome, graded from asymptomatic subclinical apoplexy to a life-threatening condition due to pituitary ischemia or haemorrhage of an enlarged pituitary gland. The risk factors and the molecular underlying mechanisms are yet to be elucidated. We provide an overview of the general concepts, the potential factors associated with pituitary adenoma susceptibility for apoplectic events and the molecular mechanisms that could be involved such as HIF-1α/VEGF pathways and metalloproteinases activation, among others. The knowledge of the molecular mechanisms that could participate in the pathogenesis of pituitary apoplexy is crucial to advancement in the identification of future diagnostic tools and therapeutic targets in this rare but sometimes fatal condition.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article de revisió ; recerca ; Versió publicada
Subject:	AIP ; Apoplexy ; Growth factors ; Hypoxia-inducing factor ; Matrix metalloproteinase ; Molecular ; Pituitary ; Review ; TNF ; VEGF
Published in:	International journal of molecular sciences, Vol. 23 Núm. 15 (august 2022) , p. 8721, ISSN 1422-0067

DOI: 10.3390/ijms23158721
PMID: 35955859

11 p, 10.1 MB

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