Comparison of the First and Second Wave of Infections by SARS-CoV-2 : A Retrospective and Longitudinal Study From a Primary Health Care Center in Santiago of Chile
Acuña-Castillo, Claudio (Universidad de Santiago de Chile)
Inostroza-Molina, Ailen (Centro de Salud Familia San José de Chuchunco)
Castro, Sergio A. (Universidad de Santiago de Chile)
Molina-Cabrera, Sonia (Centro de Salud Familia San José de Chuchunco)
Leiva-Salcedo, Elías (Universidad de Santiago de Chile)
Riquelme, Denise (Universidad de Santiago de Chile)
Luraschi, Roberto (Universidad de Santiago de Chile)
Barrera-Avalos, Carlos (Universidad de Santiago de Chile)
Vallejos Vidal, Eva Carolina (Universidad de Las Américas)
Mella-Torres, Andrea (Universidad de Santiago de Chile)
Valdés, Daniel (Universidad de Santiago de Chile)
Torres, Claudio (Drexel University)
Maisey, Kevin (Universidad de Santiago de Chile)
Escobar, Alejandro (Universidad de Chile)
Reyes-Cerpa, Sebastián (Universidad Mayor)
Toro-Ascuy, Daniela (Universidad Autónoma de Chile)
Imarai, Mónica (Universidad de Santiago de Chile)
Reyes-López, Felipe E. (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Sandino, Ana María (Universidad de Santiago de Chile)

Date:	2022
Abstract:	The current COVID-19 pandemic is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Many countries have reported the experience of at least two contagion waves, describing associated mortality rates and population behavior. The analysis of the effect of this pandemic in different localities can provide valuable information on the key factors to consider in the face of future massive infectious diseases. This work describes the first retrospective and comparative study about behavior during the first and second waves of the COVID-19 pandemic in Chile from a primary Healthcare Center. From 19,313 real-time quantitative PCR (RT-qPCR) tests assessed, the selected 1,694 positive diagnostics showed a decrease in mortality rate in the second wave (0. 6%) compared with the first (4. 6%). In addition, we observed that infections in the second wave were mainly in young patients with reduced comorbidities. The population with a complete vaccination schedule shows a decrease in the duration of symptoms related to the disease, and patients with more comorbidities tend to develop severe illness. This report provides evidence to partially understand the behavior and critical factors in the severity of the COVID-19 pandemic in the population of Santiago of Chile.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	SARS-CoV-2 ; COVID-19 ; Waves of infection ; Vaccination ; Chile
Published in:	Frontiers in Public Health, Vol. 10 (June 2022) , art. 913519, ISSN 2296-2565

DOI: 10.3389/fpubh.2022.913519
PMID: 35844873

8 p, 1.4 MB

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