Microbiome Impact on Amyloidogenesis
Seira Curto, Jofre (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Surroca Lopez, Amat (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Casals Sánchez, Maria (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Tic, Iva (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Fernández Gallegos, María Rosario (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Sánchez de Groot, Natalia (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)

Date:	2022
Abstract:	Our life is closely linked to microorganisms, either through a parasitic or symbiotic relationship. The microbiome contains more than 1,000 different bacterial species and outnumbers human genes by 150 times. Worryingly, during the last 10 years, it has been observed a relationship between alterations in microbiota and neurodegeneration. Several publications support the hypothesis that amyloid structures formed by microorganisms may trigger host proteins aggregation. In this review, we collect pieces of evidence supporting that the crosstalk between human and microbiota amyloid proteins could be feasible and, probably, a more common event than expected before. The combination of their outnumbers, the long periods of time that stay in our bodies, and the widespread presence of amyloid proteins in the bacteria Domain outline a worrying scenario. However, the identification of the exact microorganisms and the mechanisms through with they can influence human disease also opens the door to developing a new and diverse set of therapeutic strategies.
Grants:	Ministerio de Ciencia e Innovación RYC2019-026752-I Agencia Estatal de Investigación PID2020-117454RA-I00
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Microbiome ; Amyloid ; Prion ; Bacteria ; Probiotic ; Neurodegenerative disease ; Gut
Published in:	Frontiers in Molecular Biosciences, Vol. 9 (June 2022) , art. 926702, ISSN 2296-889X

DOI: 10.3389/fmolb.2022.926702
PMID: 35782871

8 p, 887.3 KB

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