Cetylpyridinium Chloride-Containing Mouthwashes Show Virucidal Activity against Herpes Simplex Virus Type 1
Riveira Muñoz, Eva (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa)
García Vidal, Edurne (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa)
Bañó Polo, Manuel (Dentaid Research Center. Department of Microbiology (Cerdanyola del Vallès, Barcelona))
León Berríos, Rubén (Dentaid Research Center. Department of Microbiology (Cerdanyola del Vallès, Barcelona))
Blanc Pociello, Vanessa (Dentaid Research Center. Department of Microbiology (Cerdanyola del Vallès, Barcelona))
Clotet Sala, Bonaventura (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa)
Ballana, Ester (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa)
Universitat Autònoma de Barcelona

Date:	2023
Abstract:	The oral cavity is particularly susceptible to viral infections that are self-recovering in most cases. However, complications may appear in severe cases and/or immunocompromised subjects. Cetylpyridinium chloride (CPC)-containing mouthwashes are able to decrease the infectivity of the SARS-CoV-2 virus by disrupting the integrity of the viral envelope. Here, we show that CPC, as the active ingredient contained in commercialized, exerts significant antiviral activity against enveloped viruses, such as HSV-1, but not against non-enveloped viruses, such as HPV. CPC-containing mouthwashes have been used as antiseptics for decades, and thus, they can represent a cost-effective measure to limit infection and spread of enveloped viruses infecting the oral cavity, aiding in reducing viral transmission.
Grants:	Generalitat de Catalunya SLT017/20/000090 Instituto de Salud Carlos III MSII19/00012
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	HSV ; HPV ; CPC ; Oral infection ; Enveloped viruses
Published in:	Viruses, Vol. 15 (june 2023) , ISSN 1999-4915

DOI: 10.3390/v15071433
PMID: 37515121

8 p, 1.1 MB

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