High conservation of the dental plaque microbiome across populations with differing subsistence strategies and levels of market integration
Velsko, Irina M. (Max Planck Institute for Evolutionary Anthropology. Department of Archaeogenetics)
Gallois, Sandrine (Leiden University)
Stahl, Raphaela (Max Planck Institute for Evolutionary Anthropology. Department of Archaeogenetics)
Henry, Amanda G. (Leiden University)
Warinner, Christina (Max Planck Institute for Evolutionary Anthropology. Department of Archaeogenetics)

Fecha:	2023
Resumen:	Industrialization-including urbanization, participation in the global food chain and consumption of heavily processed foods-is thought to drive substantial shifts in the human microbiome. While diet strongly influences stool microbiome composition, the influence of diet on the oral microbiome is largely speculative. Multiple ecologically distinct surfaces in the mouth, each harbouring a unique microbial community, pose a challenge to assessing changes in the oral microbiome in the context of industrialization, as the results depend on the oral site under study. Here, we investigated whether microbial communities of dental plaque, the dense biofilm on non-shedding tooth surfaces, are distinctly different across populations with dissimilar subsistence strategies and degree of industrialized market integration. Using a metagenomic approach, we compared the dental plaque microbiomes of Baka foragers and Nzime subsistence agriculturalists in Cameroon (n = 46) with the dental plaque and calculus microbiomes of highly industrialized populations in North America and Europe (n = 38). We found that differences in microbial taxonomic composition between populations were minimal, with high conservation of abundant microbial taxa and no significant differences in microbial diversity related to dietary practices. Instead, we find that the major source of variation in dental plaque microbial species composition is related to tooth location and oxygen availability, which may be influenced by toothbrushing or other dental hygiene measures. Our results support that dental plaque, in contrast to the stool microbiome, maintains an inherent stability against ecological perturbations in the oral environment.
Ayudas:	European Commission 677576
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Baka ; Dental plaque ; Diet ; Industrialization ; Nzime ; Oral microbiome ; Subsistence
Publicado en:	Molecular ecology, Vol. 32, Issue 14 (July 2023) , p. 3872-3891, ISSN 1365-294X

DOI: 10.1111/mec.16988
PMID: 37202853

20 p, 5.4 MB

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