000301187 001 __ 301187
000301187 005 __ 20241007145359.0
000301187 024 8_ $9 trerecprouab $9 scholar $9 primocentral $9 driver $a oai:ddd.uab.cat:301187
000301187 041 __ $a eng
000301187 100 1_ $a Gutiérrez Herraiz, Helena
000301187 245 1_ $a Targeting Porphyromonas gingivalis with ginger exosome-like nanoparticles : $b the next cure of Alzheimer?
000301187 260 __ $c 2024
000301187 520 3_ $a Alzheimer's type dementia (AD) is a debilitating neurodegenerative disorder affecting 55 million people globally. It is characterised by the presence of extracellular senile plaques and intracellular neurofibrillary tangles, consisting of amyloid beta and hyperphosphorylated tau proteins respectively. Despite global research efforts, there is currently no cure available. Porphyromonas gingivalis is a risk factor of the development of this disease. Indeed, this bacteria infects more than half of the world's population. Consequently, controlling P. gingivalis infection is key to fight against AD. However, this bacterium is resistant to broad-spectrum antibiotics; thus, a new therapy is needed to inhibit the deleterious effects of this bacteria on the brain. Ginger exosome-like nanoparticles (GELNs) attenuated the pathogenicity of P. gingivalis. This is because they reduce the expression of genes of this bacteria relationated with adhesion, hemagglutinin, proteinases, transcription factors and important components of the membrane. Consequently, GELNs can have anti-biofilm as well as antibacterial activity against P. gingivalis. Further, GELNs because of their natural source can be inexpensive produced.Therefore, this research will provide valuable information on the efficacy and applicability of GELNs to treat and prevent AD. The results of this research will guide the necessary conceptual or methodological adjustments, as well as the next steps for an exhaustive characterization and preclinical evaluation of this new promising therapeutic.
000301187 540 __ $9 open access $a Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre i quan aquestes es distribueixin sota la mateixa llicència que regula l'obra original i es reconegui l'autoria. $u https://creativecommons.org/licenses/by-sa/4.0/
000301187 546 __ $a Anglès
000301187 653 __ $a Alzheimer's disease
000301187 653 __ $a Infectious agent
000301187 653 __ $a Virulence factors
000301187 653 __ $a Therapeutic
000301187 653 __ $a Ginger
000301187 655 __ $1 http://purl.org/coar/resource_type/c_bdcc $2 openaire4 $a Treball de fi de postgrau $c literature
000301187 700 1_ $0 0000-0002-6558-3978 $a Julián Gómez, Esther, $e tut. $u Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia
000301187 710 1_ $9 113 $a Universitat Autònoma de Barcelona. $b Facultat de Biociències
000301187 740 __ $9 4313775 $a Microbiologia Aplicada
000301187 830 __ $9 1545 $a Màster Universitari en Microbiologia Aplicada
000301187 856 40 $p 33 $s 1671425 $u https://ddd.uab.cat/pub/trerecpro/2024/301187/Gutierrez_Helena_TFM_Microbiologia_Aplicada.pdf
000301187 980 __ $a TRERECPRO $b UAB