@mastersthesis{ddd.uab.cat:301187,
      author = {Gutiérrez Herraiz, Helena and Julián Gómez, Esther, tut.},
       title = {Targeting Porphyromonas gingivalis with ginger exosome-like
               nanoparticles : the next cure of Alzheimer?},
        year = {2024},
    abstract = {Alzheimer's type dementia (AD) is a debilitating
               neurodegenerative disorder affecting 55 million people globally.
               It is characterised by the presence of extracellular senile
               plaques and intracellular neurofibrillary tangles, consisting of
               amyloid beta and hyperphosphorylated tau proteins respectively.
               Despite global research efforts, there is currently no cure
               available. Porphyromonas gingivalis is a risk factor of the
               development of this disease. Indeed, this bacteria infects more
               than half of the world's population. Consequently, controlling P.
               gingivalis infection is key to fight against AD. However, this
               bacterium is resistant to broad-spectrum antibiotics; thus, a new
               therapy is needed to inhibit the deleterious effects of this
               bacteria on the brain. Ginger exosome-like nanoparticles (GELNs)
               attenuated the pathogenicity of P. gingivalis. This is because
               they reduce the expression of genes of this bacteria relationated
               with adhesion, hemagglutinin, proteinases, transcription factors
               and important components of the membrane. Consequently, GELNs can
               have anti-biofilm as well as antibacterial activity against P.
               gingivalis. Further, GELNs because of their natural source can be
               inexpensive produced.Therefore, this research will provide
               valuable information on the efficacy and applicability of GELNs
               to treat and prevent AD. The results of this research will guide
               the necessary conceptual or methodological adjustments, as well
               as the next steps for an exhaustive characterization and
               preclinical evaluation of this new promising therapeutic.},
         url = {https://ddd.uab.cat/record/301187},
}