Dog Blood Type DEA 1 in Two Municipalities of Luanda Province of Angola (Sub-Saharan Africa)
Silvestre-Ferreira, Ana C. (Universidade de Trás-os-Montes e Alto Douro. Department of Veterinary Sciences)
Vilhena, Hugo (Escola Universitária Vasco da Gama. Department of Veterinary Sciences (Coimbra, Portugal)))
Oliveira, Ana C. (Casa dos Animais Veterinary Clinic)
Mendoza, José R. (Casa dos Animais Veterinary Clinic)
Garcia Aura, Maria (Casa dos Animais Veterinary Clinic)
Pastor Milán, Josep (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals)

Fecha:	2024
Resumen:	Blood transfusions are lifesaving procedures. In dogs, because of the absence of naturally occurring alloantibodies, the risk of an acute hemolytic transfusion reaction at the first transfusion is negligible, but mismatched transfusions might produce alloimmunization. Therefore, it is important to blood type both donor and recipient dogs prior to blood transfusion. The prevalence of dog blood groups varies geographically and between breeds. The aim of this study was to determine the prevalence of DEA 1 in a canine population in Luanda province in Angola (Sub-Saharan Africa) and to assess the risk of alloimmunization after a mismatched blood transfusion. Of the 112 dogs tested (59 males and 53 females), 52. 68% were DEA 1 positive and 47. 32% DEA 1 negative. Female dogs presented a tendency to be DEA 1 positive and males DEA 1 negative (p = 0. 0085). In a first-time mismatched blood transfusion, the calculated probability of a dog becoming sensitized was 24. 9% and the probability of an acute hemolytic reaction following a second incompatible blood transfusion was 6. 21%. These results differ from those of other African regions. In line with the results, blood typing is recommended prior to transfusion. In dogs, the risk of an acute hemolytic transfusion reaction at the first transfusion is negligible; however, mismatched transfusions may produce alloimmunization. To avoid fatal acute hemolytic reactions in subsequent blood transfusions, it is important to recognize blood groups and to blood type both the donor and the recipient. Prevalence of dog blood groups varies geographically and between breeds. Our aim was to determine DEA 1 prevalence in a canine population in Luanda (Angola) and to assess alloimmunization risk after a mismatched blood transfusion. Blood samples were typed using an immunochromatographic strip technique. Of the 112 dogs tested (59 males; 53 females), 52. 68% were DEA 1 positive and 47. 32% DEA 1 negative. Females tended to be DEA 1 positive, and males DEA 1 negative (p = 0. 0085). In a first-time mismatched blood transfusion, the calculated probability of a dog becoming sensitized was 24. 9% and the probability of an acute hemolytic reaction following a second incompatible blood transfusion was 6. 21%. DEA 1 prevalence obtained was similar to that reported worldwide, but differs from other African countries. The risk of alloimmunization and acute hemolytic transfusion reactions in mismatched blood transfusions is higher than that in other African regions. Blood typing is recommended prior to transfusion.
Nota:	Altres ajuts: Portuguese Foundation for Science and Technology (FCT) UIDB/00772/2020
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Africa ; Angola ; Alloimmunization ; DEA 1 ; Blood typing ; Blood group
Publicado en:	Veterinary sciences, Vol. 11 (september 2024) , ISSN 2306-7381

DOI: 10.3390/vetsci11090449
PMID: 39330828

7 p, 224.6 KB

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