Occupational Exposures, Chronic Obstructive Pulmonary Disease and Tomographic Findings in the Spanish Population
Loeb, Eduardo (Universitat Autònoma de Barcelona. Departament de Medicina)
Zock, Jan-Paul (National Institute for Public Health and the Environment (RIVM))
Miravitlles, Marc (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Rodríguez, Esther (Hospital Universitari Vall d'Hebron)
Kromhout, Hans (Utrecht University)
Vermeulen, Roel (Utrecht University)
Soler-Cataluña, Juan José (Hospital Arnau de Vilanova (València))
Soriano, Joan B.. (Hospital Universitario de la Princesa (Madrid))
García-Rio, Francisco (Hospital Universitario La Paz (Madrid))
de Lucas-Ramos, Pilar (Hospital General Universitario Gregorio Marañón)
Alfageme, Inmaculada (Hospital Universitario Virgen de Valme (Sevilla, Andalusia))
Casanova, Ciro (Hospital Universitario Nuestra Señora de Candelaria (Santa Cruz de Tenerife))
Rodríguez González-Moro, José Miguel (Hospital Universitario Vithas Madrid Arturo Soria)
Ancochea, Julio (Hospital Universitario de la Princesa (Madrid))
Cosio, Borja G (Hospital Universitari Son Espases (Palma de Mallorca, Balears))
Ferrer Sancho, Jaume 1958- (Hospital del Mar (Barcelona, Catalunya))

Date:	2024
Abstract:	Self-reported occupational exposure was previously associated with COPD in the Spanish population. This study aimed to analyse the relationship between occupational exposure to various chemical and biological agents, COPD, emphysema, and the bronchial wall area, which was determined by lung computed tomography (CT) in 226 individuals with COPD and 300 individuals without COPD. Lifetime occupational exposures were assessed using the ALOHA(+) job exposure matrix, and CT and spirometry were also performed. COPD was associated with high exposure to vapours, gases, dust and fumes (VGDF) (OR 2. 25 95% CI 1. 19-4. 22), biological dust (OR 3. 01 95% CI 1. 22-7. 45), gases/fumes (OR 2. 49 95% CI 1. 20-5. 17) and with exposure to various types of solvents. High exposure to gases/fumes, chlorinated solvents and metals (coefficient 8. 65 95% CI 1. 21-16. 09, 11. 91 95%CI 0. 46- 23. 36, 14. 45 95% CI 4. 42-24. 49, respectively) and low exposure to aromatic solvents (coefficient 8. 43 95% CI 1. 16-15. 70) were associated with a low 15th percentile of lung density indicating emphysema. We conclude that occupational exposure to several specific agents is associated with COPD and emphysema in the Spanish population.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Chronic obstructive pulmonary disease ; COPD ; Occupational exposures ; Job exposure matrix ; JEM ; Computed tomography ; Emphysema
Published in:	Toxics, Vol. 12 Núm. 10 (september 2024) , ISSN 2305-6304

DOI: 10.3390/toxics12100689
PMID: 39453109

13 p, 292.1 KB

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