Astrocytic outer retinal layer thinning is not a feature in AQP4-IgG seropositive neuromyelitis optica spectrum disorders
Lu, Angelo (Charité-Universitätsmedizin Berlin)
Zimmermann, Hanna G (Charité-Universitätsmedizin Berlin)
Specovius, Svenja (Charité-Universitätsmedizin Berlin)
Motamedi, Seyedamirhosein (Charité-Universitätsmedizin Berlin)
Chien, Claudia (Charité-Universitätsmedizin Berlin)
Bereuter, Charlotte (Charité-Universitätsmedizin Berlin)
Lana-Peixoto, Marco A (University of Minas Gerais State, Medical School)
Fontenelle, Mariana Andrade (University of Minas Gerais State, Medical School)
Ashtari, Fereshteh (Isfahan University of Medical Sciences)
Kafieh, Rahele (Isfahan University of Medical Sciences)
Dehghani, Alireza (Isfahan University of Medical Sciences)
Pourazizi, Mohsen (Isfahan University of Medical Sciences)
Pandit, Lekha (Nitte University)
D'Cunha, Anitha (Nitte University)
Kim, Ho Jin (National Cancer Center Korea)
Hyun, Jae-Won (National Cancer Center Korea)
Jung, Su-Kyung (Research Institute and Hospital of National Cancer Center)
Leocani, Letizia (Vita Salute San Raffaele University)
Pisa, Marco (Hospital Vita Salute San Raffaele University)
Radaelli, Marta (Vita Salute San Raffaele University)
Siritho, Sasitorn (Siriraj Hospital and Bumrungrad International Hospital)
May, Eugene F (Swedish Neuroscience Institute Neuro-Ophthalmology)
Tongco, Caryl (Swedish Neuroscience Institute Neuro-Ophthalmology)
De Sèze, Jérôme (University Hospital of Strasbourg)
Senger, Thomas (University Hospital of Strasbourg)
Palace, Jacqueline (Oxford University Hospitals NHS Trust)
Roca-Fernández, Adriana (Oxford University Hospitals NHS Trust)
Leite, Maria Isabel (Oxford University Hospitals NHS Trust)
Sharma, Srilakshmi M (Oxford University Hospitals NHS Trust)
Stiebel-Kalish, Hadas (Tel Aviv University)
Asgari, Nasrin (University of Southern Denmark)
Soelberg, Kerstin Kathrine (University of Southern Denmark)
Martinez-Lapiscina, Elena H (Hospital Clínic i Provincial de Barcelona)
Havla, Joachim (Ludwig-Maximilians-Universität München)
Mao-Draayer, Yang (University of Michigan Medical School)
Rimler, Zoe (NYU Multiple Sclerosis Comprehensive Care Center)
Reid, Allyson (NYU Multiple Sclerosis Comprehensive Care Center)
Marignier, Romain (Hospital for Neurology Pierre Wertheimer)
Cobo-Calvo, Álvaro (Universitat Autònoma de Barcelona)
Altintas, Ayse (Koc University School of Medicine)
Tanriverdi, Uygur (Istanbul University-Cerrahpaşa)
Yildirim, Rengin (Istanbul Universitesi)
Aktas, Orhan (Heinrich-Heine-Universität Düsseldorf)
Ringelstein, Marius (Heinrich-Heine-Universität Düsseldorf)
Albrecht, Philipp (Heinrich-Heine-Universität Düsseldorf)
Tavares, Ivan Maynart (Universidade Federal de São Paulo)
Bichuetti, Denis Bernardi (Universidade Federal de São Paulo)
Jacob, Anu (The Walton Centre NHS Foundation Trust)
Huda, Saif (The Walton Centre NHS Foundation Trust)
Soto de Castillo, Ibis (Hospital Clinico de Maracaibo)
Petzold, Axel (University College London)
Green, Ari J (University of California San Francisco)
Yeaman, Michael R (University of California Los Angeles)
Smith, Terry J (University of Michigan Medical School)
Cook, Lawrence (University of Utah Health)
Paul, Friedemann (Charité-Universitätsmedizin Berlin)
Brandt, Alexander U (University of California Irvine)
Oertel, Frederike Cosima (University of California San Francisco)

Fecha:	2021
Resumen:	Patients with anti-aquaporin-4 antibody seropositive (AQP4-IgG+) neuromyelitis optica spectrum disorders (NMOSDs) frequently suffer from optic neuritis (ON) leading to severe retinal neuroaxonal damage. Further, the relationship of this retinal damage to a primary astrocytopathy in NMOSD is uncertain. Primary astrocytopathy has been suggested to cause ON-independent retinal damage and contribute to changes particularly in the outer plexiform layer (OPL) and outer nuclear layer (ONL), as reported in some earlier studies. However, these were limited in their sample size and contradictory as to the localisation. This study assesses outer retinal layer changes using optical coherence tomography (OCT) in a multicentre cross-sectional cohort. 197 patients who were AQP4-IgG+ and 32 myelin-oligodendrocyte-glycoprotein antibody seropositive (MOG-IgG+) patients were enrolled in this study along with 75 healthy controls. Participants underwent neurological examination and OCT with central postprocessing conducted at a single site. No significant thinning of OPL (25. 02±2. 03 µm) or ONL (61. 63±7. 04 µm) were observed in patients who were AQP4-IgG+ compared with patients who were MOG-IgG+ with comparable neuroaxonal damage (OPL: 25. 10±2. 00 µm; ONL: 64. 71±7. 87 µm) or healthy controls (OPL: 24. 58±1. 64 µm; ONL: 63. 59±5. 78 µm). Eyes of patients who were AQP4-IgG+ (19. 84±5. 09 µm, p=0. 027) and MOG-IgG+ (19. 82±4. 78 µm, p=0. 004) with a history of ON showed parafoveal OPL thinning compared with healthy controls (20. 99±5. 14 µm); this was not observed elsewhere. The results suggest that outer retinal layer loss is not a consistent component of retinal astrocytic damage in AQP4-IgG+ NMOSD. Longitudinal studies are necessary to determine if OPL and ONL are damaged in late disease due to retrograde trans-synaptic axonal degeneration and whether outer retinal dysfunction occurs despite any measurable structural correlates.
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Vision ; Clinical neurology ; Ophthalmology
Publicado en:	Journal of Neurology, Neurosurgery, and Psychiatry, Vol. 93 (october 2021) , p. 188-195, ISSN 1468-330X

DOI: 10.1136/jnnp-2021-327412
PMID: 34711650

8 p, 1.6 MB

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