Immunohistochemical Expression of Tenascin-C in Canine Meningiomas
Sant'Ana, Fabiano (Universidade de Brasília. Laboratório de Diagnóstico Patológico Veterinário)
Blasco, Ester (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals)
Pumarola i Batlle, Martí (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals)

Fecha:	2024
Resumen:	Many studies have analyzed the relationship between the different subtypes of canine meningiomas and prognostic immunohistochemical markers. However, the expression of tenascin-C (TN-C), an extracellular matrix glycoprotein, in canine meningiomas has not been performed. Twenty-one cases of canine meningioma were analyzed. The immunoreactivity of TN-C was mild in grade I, moderate in grade II, and moderate to severe in grade III neoplasms. Immune positivity was observed in the stroma and perivascular space in all subtypes. In addition, the concentric whorls of neoplastic cells were labeled positive in some psammomatous and transitional meningiomas. The reaction to TN-C was more significant in grade II and III tumors. The immunohistochemical findings of the current study suggest that TN-C can act as a stromal marker, mainly in grade II or III meningiomas. In humans, tenascin-C (TN-C) expression has been detected in more aggressive neoplasms of the central nervous system, such as gliomas and meningiomas. No study has analyzed the immune expression of TN-C in canine meningioma. The current study aimed to investigate the immunohistochemical distribution of TN-C in different grades of canine meningiomas. Twenty-one cases of canine meningioma (12 grade I, 6 grade II, and 3 grade III) were analyzed. All samples were examined by immunohistochemistry with the following antibodies: TN-C, epithelial membrane antigen (EMA), Ki-67, pan-cytokeratin (Pan CK), and vimentin. The histopathological diagnosis of meningioma was reinforced with the positive labeling of vimentin (moderate to strong) and EMA (mild to moderate) in neoplastic cells in most cases, independently of its grade or subtype. The immunoreactivity of TN-C was irregular: mild in grade I, moderate in grade II, and moderate to severe in grade III neoplasms. Usually, immune positivity was observed in the stroma and perivascular space in all subtypes. In addition, the concentric whorls of neoplastic cells were labeled positive in some psammomatous and transitional meningiomas. The reaction to TN-C was more significant in grade II and III tumors. The immunohistochemical findings of the current study suggest that TN-C can act as a stromal marker, mainly in grade II or III meningiomas.
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Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Neuropathology ; Meningioma ; Oncology ; TN-C
Publicado en:	Veterinary sciences, Vol. 11 (october 2024) , ISSN 2306-7381

DOI: 10.3390/vetsci11100462
PMID: 39453053

8 p, 3.6 MB

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