Beta-Glucans Improve the Mammary Innate Immune Response to Endotoxin Challenge in Dairy Ewes
Guamàn Rivera, Santiago Alexander (Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments)
El Hadi, Abdelaali (Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments)
Salama, Ahmed A. K (Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments)
Manuelian, Carmen L (Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments)
Caja López, Gerardo (Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments)
Albanell Trullas, Elena (Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments)

Fecha:	2024
Resumen:	Barley grains contain a variable amount of biologically active compounds such as β-glucans (BGs) which are important in nutrition due to their relationship with improvements of the immune system and resistance against pathogens. Although barley is a cereal widely used in the diet of ruminants, to our best knowledge, there are no studies on the effect of using barley BG as a functional feed ingredient for modulating the immune system in ruminants. Therefore, the aim of this study was to evaluate the short-term immune responses of dairy ewes supplemented with barley BG when submitted to an intramammary lipopolysaccharide challenge. The results showed the potentiality of barley BG as a biological agent to induce immune activation of dairy ewes against E. coli endotoxin. However, further studies should be performed to support our findings. This study evaluated short-term immune responses of dairy ewes supplemented with barley β-glucan (BG) following an intramammary Escherichia coli lipopolysaccharide (LPS) challenge. In the adaptation period, 36 ewes were fed an alfalfa hay diet ad libitum and barley grain cv. Hispanic (3. 8% BG). Then, ewes were assigned into three experimental groups: (1) Control (CON), the same previous diet (13. 3 g BG/d); (2) high β-glucans barley (HBG), new barley (cv. Annapurna) containing 10% BG (35 g BG/d); (3) intraperitoneally injected (INP) with a 1. 4% BG solution dose (2 g BG/ewe). At d 9, all ewes were infused with an E. coli LPS or saline solution in each udder half. After the challenge, rectal temperature (RT), milk yield and composition, somatic cell count (SCC), and plasma interleukins (IL-1α and IL-1β) were monitored daily. The INP treatment revealed a transitory increase in RT and decreased milk yield by 38%. Milk fat, protein, and SCC increased in LPS-treated udders but not by BG treatment. The IL-1α plasma concentration was similar among groups but INP ewes showed a lower IL-1β concentration suggesting a lower inflammatory response. The BG administration appears more effective intraperitoneally than orally, which needs additional study.
Ayudas:	Agencia Estatal de Investigación AGL2015-69435-C3-3-R
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Β-glucans ; Immunity ; LPS challenge ; Barley ; Dairy sheep
Publicado en:	Animals, Vol. 14 (october 2024) , ISSN 2076-2615

DOI: 10.3390/ani14203023
PMID: 39457952

14 p, 1.2 MB

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