| Resumen: |
The erythrocyte sedimentation rate (ESR) has been increasingly used in canine medicine to assess inflammation levels. In this study, the ESR was compared to several inflammatory and immune response markers, typically investigated in dogs with canine leishmaniasis (CanL) and in dogs affected by other inflammatory conditions. Three groups of dogs were included in the study: CanL affected dogs without clinical signs (INFECTED, #25) or with clinical signs (SICK, #43), and dogs affected by acute or acute-on-chronic conditions (OTHER DISEASE, #65). The ESR and several inflammatory (i. e. , C reactive protein, fibrinogen, haptoglobin, and ferritin,) or immunological parameters (i. e. , total proteins, gamma-globulins, IgG, and IgM) were compared between groups and correlated. The ESR was statistically higher in the SICK group and in the OTHER DISEASE group than in the INFECTED group. ESR values may therefore help to stage the severity of CanL. In addition, as a point-of-care assay, the ESR could be used to screen the health status of dogs with its values being related to the severity of any disease. The erythrocyte sedimentation rate (ESR) has been used in canine medicine in several disorders, above all, to evaluate levels of inflammation. This study evaluated the ESR in canine leishmaniosis (CanL) and other inflammatory conditions. Three groups of dogs were examined: CanL affected dogs without clinical signs (INFECTED group, #25) or with clinical signs (SICK group, #43) and dogs affected by acute or acute-on-chronic conditions (OTHER DISEASE group, #65). The ESR was compared with acute phase proteins or reactants either positive or negative (leukogram, fibrinogen, iron, unsaturated iron binding capacity, ferritin, haptoglobin, and albumin) and immunological markers (gamma-globulins, IgG, and IgM). The ESR was higher in the SICK group than in the INFECTED group (median 39 vs. 11 mm/h; p < 0. 0001), as well as in the OTHER DISEASE than in the INFECTED groups (median 41 vs. 11 mm/h; p < 0. 0001). The ESR appeared outside the reference range for all dogs in the SICK and OTHER DISEASE groups and almost with similar values (mm/h; median 39, 95% CI 31-51 vs. 41, 95% CI 12-87; p > 0. 05). The extent of changes in ESR can help to establish the severity of CanL and other inflammatory disorders. As a point-of-care test, the ESR can be used to screen dogs for unhealthy conditions, and its values correlate with the severity of any disease, including CanL. |
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identificación
(Clinica Veterinaria Colombo)
