Mometasone furoate and fluticasone furoate are equally effective in restoring nasal epithelial barrier dysfunction in allergic rhinitis
Doulaptsi, Maria (University of Crete School of Medicine (Creta, Grècia))
Wils, Tine (KU Leuven Department of Microbiology, Immunology and Transplantation, Allergy and Clinical Immunology Research group (Leuven, Bèlgica))
Hellings, Peter W. (UZ Leuven)
Martens, Katleen (KU Leuven Department of Microbiology, Immunology and Transplantation, Allergy and Clinical Immunology Research group (Leuven, Bèlgica))
Farré, Ricard (KU Leuven, Department of Chronic Diseases, Metabolism and Ageing, Translational Research Center for Gastrointestinal Disorders (Leuven, Bèlgica))
Vicario Perez, Maria (Vall d'Hebron Institut de Recerca (VHIR))
Fokkens, Wytske (Academic Medical Center (Amsterdam, Països Baixos))
Prokopakis, Emmanuel (University of Crete School of Medicine (Creta, Grècia))
Steelant, Brecht (KU Leuven Department of Microbiology, Immunology and Transplantation, Allergy and Clinical Immunology Research group(Leuven, Bèlgica))

Date:	2021
Abstract:	Tight junction defects (TJ) have been associated with a defective epithelial barrier function in allergic rhinitis (AR). Intranasal corticosteroids are potent drugs frequently used to treat AR and are shown to restore epithelial integrity by acting on TJs and by reducing type 2 cytokine production. However, the effect of different classes of intranasal corticosteroids on the epithelial barrier has not been studied. Therefore, we compared the effect of 2 intranasal corticosteroids, ie, fluticasone furoate (FF) and mometasone furoate (MF) on epithelial barrier function. Both FF and MF similarly increased trans-epithelial electrical resistance of primary nasal epithelial cell cultures from AR patients. In a house dust mite-induced allergic asthma mouse model, FF and MF had similar beneficial effects on fluorescein isothiocyanate-dextran 4 kDa mucosal permeability, eosinophilic infiltration and IL-13 levels. Both molecules increased mRNA expression of the TJ proteins occludin and zonula occludens-1, thereby restoring epithelial barrier function. Lastly, we showed that long-term FF treatment also increased expression of occludin in AR patients compared to controls. In conclusion, both FF and MF effectively restore epithelial barrier function by increasing expression of TJ proteins in AR patients.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Fluticasone furoate ; Mometasone furoate ; Tight junctions ; Epithelial integrity ; Allergic rhinitis
Published in:	The World Allergy Organization Journal, Vol. 14 (september 2021) , ISSN 1939-4551

DOI: 10.1016/j.waojou.2021.100585
PMID: 34567350

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