COVID-19 IgG seropositivity and its determinants in occupational groups of varying infection risks in two Andean cities of Ecuador before mass vaccination
Leon-Rojas, José E. (Universitat Autònoma de Barcelona. Departament de Pediatria, Obstetrícia i Ginecologia i de Medicina Preventiva i Salut Pública)
Arias-Erazo, Fernanda (Universidad Internacional del Ecuador)
Jiménez-Arias, Patricia (Universidad Internacional del Ecuador)
Recalde-Navarrete, Ricardo (Universidad Internacional del Ecuador)
Guevara, Ángel (Universidad Central del Ecuador)
Coloma, Josefina (University of California)
Martin, Miguel (Universidad Internacional del Ecuador)
Chis Ster, Irina (St George's University of London)
Cooper, Philip (St George's University of London)
Romero-Sandoval, Natalia (Universidad Internacional del Ecuador)

Fecha:	2024
Resumen:	The COVID-19 pandemic has caused over 68. 7 million infections and 1. 35 million deaths in South America. There are limited data on SARS-CoV-2 seropositivity and its determinants from Andean countries prior to mass vaccinations against COVID-19. To estimate SARS-CoV-2 seropositivity and its determinants before vaccination in occupational groups of adults presumed to have different levels of exposure and associations with potential symptomatology. We measured seropositivity of anti-SARS-CoV-2 IgG antibodies in a cross-sectional study of vaccine-naïve adults aged 18 years and older, recruited within three occupational risk groups (defined as low [LR], moderate [MR], and high [HR]) between January and September 2021 in two Andean cities in Ecuador. Associations with risk factors were estimated using logistic regression. In a sample of 882 adults, IgG seropositivity for the three different occupational risk groups was 39. 9% (CI 95% 35. 3-44. 6), 74. 6% (CI 95% 66. 4-81. 4), and 39. 0% (CI 95% 34. 0-44. 4) for the HR, MR, and LR groups, respectively. History of an illness with loss of taste and/or smell was significantly associated with seropositivity in all occupational groups, with adjusted ORs of 14. 31 (95%CI, 5. 83-35. 12; p<0. 001), 14. 34 (95%CI 3. 01-68. 42; p<0. 001), and 8. 79 (95%CI 2. 69-28. 72; p<0. 001), for the HR, MR, and LR groups, respectively; while fever was significant for the LR group with an adjusted OR of 1. 24 (95%CI, 1. 11-4. 57; p = 0. 025) and myalgia for the HR group with an adjusted OR of 2. 07 (95%CI, 1. 13-3. 81; p = 0. 019). Notable proportions of seropositivity were seen in all occupational groups between January and September 2021 prior to mass vaccination. Loss of taste and/or smell was strongly associated with presence of anti-SARS-CoV-2 IgG antibodies irrespective of presumed occupational exposure risk.
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Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Publicado en:	PloS one, Vol. 19 (august 2024) , ISSN 1932-6203

DOI: 10.1371/journal.pone.0309466
PMID: 39208200

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