Association of exposure to second-hand smoke during childhood with blood DNA methylation
Cosin-Tomas, Marta (Universitat Pompeu Fabra)
Hoang, Thanh (Texas Children's Hospital. Cancer and Hematology Center)
Qi, Cancan (Groningen Research Institute for Asthma and COPD)
Monasso, Giulietta S. (University Medical Center Rotterdam. Department of Pediatrics)
Langdon, Ryan (University of Bristol)
Kebede Merid, Simon (Karolinska Institutet (Estocolm, Suècia))
Calas, Lucinda (Université Sorbonne Paris Nord. Center for Research in Epidemiology and StatisticS)
de Prado-Bert, Paula (Universitat Pompeu Fabra)
Richmond, Rebecca (University of Bristol)
Jaddoe, Vincent V. W. (University Medical Center Rotterdam. Department of Pediatrics)
Duijts, Liesbeth (University Medical Center Rotterdam. Department of Neonatal and Pediatric Intensive Care)
Wright, John (Bradford Institute for Health Research)
Annesi-Maesano, Isabella (Université Sorbonne Paris Nord. Center for Research in Epidemiology and StatisticS)
Grazuleviciene, Regina (Vytautas Magnus University. Department of Environmental Sciences)
Karachaliou, Marianna (University of Crete. Clinic of preventive and Social Medicine)
Koppelman, Gerard H. (Groningen Research Institute for Asthma and COPD)
Melén, Erik (Karolinska Institutet. Department of Clinical Science and Education)
Gruzieva, Olena (Karolinska Institutet (Estocolm, Suècia). Institute of Environmental Medicine)
Vrijheid, Martine (Universitat Pompeu Fabra)
Yousefi, Paul (University of Bristol)
Felix, Janine F. (University Medical Center Rotterdam. Department of Pediatrics)
London, Stephanie J. (National Institute of Environmental Health Sciences)
Bustamante, Mariona (Universitat Pompeu Fabra)

Fecha:	2025
Resumen:	Introduction: By recent estimates, 40% of children worldwide are exposed to second-hand smoke (SHS), which has been associated with adverse health outcomes. While numerous studies have linked maternal smoking during pregnancy (MSDP) to widespread differences in child blood DNA methylation (DNAm), research specifically examining postnatal SHS exposure remains sparse. To address this gap, we conducted epigenome-wide meta-analyses to identify associations of postnatal SHS and child blood DNAm. Methods: Six cohorts from the Pregnancy And Childhood Epigenetics (PACE) Consortium (total N = 2,695), with SHS data and child blood DNAm (aged 7-9 years) measured with the Illumina 450K array were included in the meta-analysis. Linear regression models adjusted for covariates were fitted to examine the association between the number of household smokers in postnatal life (0, 1, 2+) and child blood DNAm. Sensitivity models without adjusting for MSDP and restricted to mothers who did not smoke during pregnancy were evaluated. Results: Our analysis revealed significant associations (False Discovery Rate < 0. 05) between household postnatal SHS exposure and DNAm at 11 CpGs in exposed children. Nine CpGs were mapped to genes (MYO1G, FAM184B, CTDSPL2, LTBP3, PDE10A, and FIBCD1), while 2 CpGs were located in open sea regions. Notably, all except 2 CpGs (mapped to FIBCD1 and CTDSPL2) have previously been linked to either personal smoking habits or in utero exposure to smoking. The models restricted to non-smoking mothers provided similar results. Importantly, several of these CpGs and their associated genes are implicated in conditions exacerbated by or directly linked to SHS. Conclusions: Our findings highlight the potential biological effects of SHS on blood DNAm. These findings support further research on epigenetic factors mediating deleterious effects of SHS on child health and call for public health policies aimed at reducing exposure, particularly in environments where children are present.
Ayudas:	European Commission 874583 Agència de Gestió d'Ajuts Universitaris i de Recerca 2019/BP-00107 Agencia Estatal de Investigación CEX2023-0001290-S European Commission 733206 European Commission 874739
Nota:	Altres ajuts: CERCA Programme/Generalitat de Catalunya
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	450K array ; Blood DNA methylation ; Children ; DNA methylation ; Maternal smoking during pregnancy ; Passive smoking ; Postnatal exposure ; SDG 3 - Good Health and Well-being
Publicado en:	Environment International, Vol. 195 (January 2025) , art. 109204, ISSN 1873-6750

DOI: 10.1016/j.envint.2024.109204
PMID: 39693780

10 p, 1.2 MB

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