Simulation and computational analysis of multiscale graph agent-based tumor model
Tashakor, Ghazal (Universitat Autònoma de Barcelona. Departament d'Arquitectura de Computadors i Sistemes Operatius)
Suppi, Remo (Universitat Autònoma de Barcelona. Departament d'Arquitectura de Computadors i Sistemes Operatius)

Date:	2020
Description:	7 pàg.
Abstract:	This paper deals with the cellular biological network analysis of the tumor-growth model, consisting of multiple spaces and time scales. In this paper, we present a model in graph simulation using ABM for tumor growth. In particular, we propose a graph agent-based modeling and simulation system in the format of tumor growth scenario for evolving analysis. To manage cellular biological network analysis, we developed a workflow that allows us to estimate the tumor model and the complexity of the evolving behavior in a principled manner. By developing the model using Python, which has enabled us to run the model multiple times (more than what is possible by conventional means) to generate a large amount of data, we have succeeded in getting deep in to the micro-environment of the tumor, employing network analysis. Combining agent-based modeling with graph-based modeling to simulate the structure, dynamics, and functions of complex networks is exclusively important for biological systems with a large number of open parameters, e. g. , epidemic models of disease spreading or cancer. Extracting data from evolutionary directed graphs and a set of centrality algorithms helps us to tackle the problems of pathway analysis and to develop the ability to predict, control, and design the function of metabolisms. Reproducing and performing complex parametric simulations a known phenomenon at a sufficient level of detail for computational biology could be an impressive achievement for fast analysis purposes in clinics, both on the predictive diagnostic and therapeutic side.
Grants:	Agencia Estatal de Investigación TIN2017-84875-P
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Language:	Anglès
Document:	Capítol de llibre ; recerca ; Versió acceptada per publicar
Subject:	Agent based modeling ; Graph-based modeling ; Multi scale modeling ; Tumor agent-based model
Published in:	2019 International Conference on High Performance Computing & Simulation (HPCS), 2020, p. 298-304, ISBN 9781728144849

DOI: 10.1109/HPCS48598.2019.9188125

Postprint 8 p, 914.6 KB

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