Tailoring the Architecture of Cationic Polymer Brush-Modified Carbon Nanotubes for Efficient siRNA Delivery in Cancer Immunotherapy
Li, Danyang (King's College London)
Ahmed, Momina (King's College London)
Khan, Anisah (King's College London)
Xu, Lizhou (King's College London)
Walters, Adam A. (King's College London)
Ballesteros, Belén (Institut Català de Nanociència i Nanotecnologia)
Al-Jamal, Khuloud T. (King's College London)

Date:	2021
Abstract:	The facile and controlled fabrication of homogeneously grafted cationic polymers on carbon nanotubes (CNTs) remains poorly investigated, which further hinders the understanding of interactions between functionalized CNTs with different nucleic acids and the rational design of appropriate gene delivery vehicles. Herein, we describe the controlled grafting of cationic poly(2-dimethylaminoethylmethacrylate) brushes on CNTs via surface-initiated atom transfer radical polymerization integrated with mussel-inspired polydopamine chemistry. The binding of nucleic acids with different brush-CNT hybrids discloses the highly architectural-dependent behavior with dense short brush-coated CNTs displaying the highest binding among all the other hybrids, namely, dense long, sparse long, and sparse short brush-coated CNTs. Additionally, different chemistries of the brush coatings were shown to influence the biocompatibility, cellular uptake, and silencing efficiency in vitro. This platform provides great flexibility for the design of polymer brush-CNT hybrids with precise control over their structure-activity relationship for the rational design of nucleic acid delivery systems.
Grants:	Ministerio de Economía y Competitividad SEV-2017-0706 Agència de Gestió d'Ajuts Universitaris i de Recerca 2017/SGR-327
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Language:	Anglès
Document:	Article ; recerca ; Versió acceptada per publicar
Published in:	ACS applied materials & interfaces, Vol. 13, Issue 26 (July 2021) , p. 30284-30294, ISSN 1944-8252

DOI: 10.1021/acsami.1c02627

Postprint 35 p, 1.8 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Experimental sciences > Catalan Institute of Nanoscience and Nanotechnology (ICN2)
Articles > Research articles
Articles > Published articles