The Link between Abdominal Obesity Indices and the Progression of Liver Fibrosis : Insights from a Population-Based Study
Julián, María Teresa (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Arteaga, Ingrid (Institut Català de la Salut. Gerència Territorial Metropolitana Nord)
Torán Montserrat, Pere (Institut Germans Trias i Pujol)
Pera, Guillem (Institut Universitari d'Investigació en Atenció Primària Jordi Gol)
Pérez-Montes de Oca, Alejandra (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Ruiz-Rojano, Irene (Institut Universitari d'Investigació en Atenció Primària Jordi Gol)
Casademunt-Gras, Elena (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Chacón, Carla (Universitat de Barcelona. Facultat de Medicina i Ciències de la Salut)
Alonso Pedrol, Núria (Universitat Autònoma de Barcelona. Departament de Medicina)

Date:	2024
Abstract:	There is currently no available information on the correlation between abdominal obesity indices and the risk of liver fibrosis progression. We aimed to investigate the relationship between the body mass index (BMI), waist circumference (WC), and the visceral adiposity index (VAI) with the progression of liver fibrosis. The study also evaluated the association between these indices and the prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD) and liver fibrosis. A total of 1403 subjects participated in the cross-sectional and longitudinal population-based study. Liver stiffness was assessed via transient elastography, at baseline and follow-up (median: 4. 2 years). The subgroup with dysglycemia was also analyzed. In the cross-sectional study, the highest quartile of VAI, BMI ≥ 30 kg/m 2, and abdominal obesity showed significant associations with the prevalence of MASLD and liver fibrosis, as well as with fibrosis progression. However, VAI showed no association with MASLD incidence. Among the dysglycemic subjects, there was no observed association between VAI and the incidence of MASLD or the progression of fibrosis. In conclusion, the BMI, WC, and the VAI are associated with an increased risk of progression to moderate-to-advanced liver fibrosis in the general population. However, the VAI does not perform better than the BMI and WC measurement.
Grants:	Ministerio de Economía y Competitividad PI14/00407 Instituto de Salud Carlos III PI17/01362 Instituto de Salud Carlos III PI21/00817 Ministerio de Economía y Competitividad PI16/00043
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Metabolic dysfunction-associated steatotic liver disease (MASLD) ; Liver fibrosis ; Transient elastography (TE) ; Visceral adiposity index (VAI) ; Abdominal obesity ; Body mass index (BMI) ; Waist circumference (WC)
Published in:	Nutrients, Vol. 16 (may 2024) , ISSN 2072-6643

DOI: 10.3390/nu16111586
PMID: 38892518

16 p, 2.4 MB

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