Design and synthesis of unnatural coordination glycopolymer particles (CGPs) : unleashing the potential of catechol-saccharide derivatives
Bideplán-Moyano, Celina (Universidad Nacional del Sur (Argentina))
Lo Fiego, Marcos J. (Universidad Nacional del Sur (Argentina))
Calmels, Juan José (Universidad Nacional del Sur (Argentina))
Alonso, Belén (Universidad Nacional del Sur (Argentina))
Radivoy, Gabriel (Universidad Nacional del Sur (Argentina))
Ruiz-Molina, Daniel (Institut Català de Nanociència i Nanotecnologia)
Mancebo Aracil, Juan (Universidad Nacional del Sur (Argentina))
Nador, Fabiana (Universidad Nacional del Sur (Argentina))

Fecha:	2023
Resumen:	Our study unveils an innovative methodology that merges catechols with mono- and disaccharides, yielding a diverse array of compounds. This strategic fusion achieves robust yields and introduces ligands with a dual nature: encompassing both the chelating attributes of catechols and the recognition capabilities of carbohydrates. This synergistic design led us to couple one of the novel ligands with an Fe() salt, resulting in the creation of Coordination Glycopolymer Particles (CGPs). These CGPs demonstrate remarkable qualities, boasting outstanding dispersion in both aqueous media and Phosphate Buffered Saline (PBS) solution (pH ∼7. 4) at higher concentrations (0. 26 mg μL -1). Displaying an average Z-size of approximately 55 nm and favourable polydispersity indices (<0. 25), these particles exhibit exceptional stability, maintaining their integrity over prolonged periods and temperature variations. Notably, they retain their superior dispersion and stability even when subjected to freezing or heating to 40 °C, making them exceptionally viable for driving biological assays. In contrast to established methods for synthesizing grafted glycopolymers, where typically a glycopolymer is doped with catechol derivatives to create synergy between chelating properties and those inherent to the saccharide, our approach provides a more efficient and versatile pathway for generating CGPs. This involves combining catechols and carbohydrates within a single molecule, enabling the fine-tuning of organic structure from a monomer design step and subsequently transferring these properties to the polymer. Expanding catechol-saccharide compounds: synthesis with chelating properties and recognition capabilities, generating Coordination Glycopolymer Particles (CGPs) for stable and well-dispersed biological assays.
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Publicado en:	RSC advances, Vol. 13 (September 2023) , p. 27491-27500, ISSN 2046-2069

DOI: 10.1039/d3ra05316d
PMID: 37711379

10 p, 839.7 KB

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Documentos de investigación > Documentos de los grupos de investigación de la UAB > Centros y grupos de investigación (producción científica) > Ciencias > Institut Català de Nanociència i Nanotecnologia (ICN2)
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